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• W3126965711 abstract "Abstract Special AT-rich binding protein-1 (SATB1) integrates higher-order chromatin architecture with gene regulation, thereby regulating multiple signaling pathways. In mammalian cells SATB1 directly interacts with β-catenin and regulates the expression of Wnt targets by binding to their promoters. Whether SATB1 regulates Wnt/wg signaling by recruitment of β-catenin and/or its interactions with other components remains elusive. Since Wnt/Wg signaling is conserved from invertebrates to humans, we investigated SATB1 functions in regulation of Wnt/Wg signaling by using mammalian cell-lines and Drosophila . Here, we present evidence that in mammalian cells, SATB1 interacts with Dishevelled, an upstream component of the Wnt/Wg pathway. Conversely, ectopic expression of full-length human SATB1 but not that of its N- or C-terminal domains in the eye imaginal discs and salivary glands of third instar Drosophila larvae increased the expression of Wnt/Wg pathway antagonists and suppressed phenotypes associated with activated Wnt/Wg pathway. These data argue that ectopically-provided SATB1 presumably modulates Wnt/Wg signaling by acting as negative regulator in Drosophila . Interestingly, comparison of SATB1 with PDZ- and homeo-domain containing Drosophila protein Defective Proventriculus suggests that both proteins exhibit limited functional similarity in the regulation of Wnt/Wg signaling in Drosophila . Collectively, these findings indicate that regulation of Wnt/Wg pathway by SATB1 is context-dependent." @default.
• W3126965711 created "2021-02-15" @default.
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• W3126965711 date "2021-02-09" @default.
• W3126965711 modified "2023-10-11" @default.
• W3126965711 title "Global chromatin organizer SATB1 acts as a context-dependent regulator of the Wnt/Wg target genes" @default.
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• W3126965711 doi "https://doi.org/10.1038/s41598-021-81324-2" @default.
• W3126965711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7873079" @default.
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