Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126989464> ?p ?o ?g. }
- W3126989464 abstract "Streptococcus pneumoniae is an opportunistic respiratory human pathogen that poses a continuing threat to human health. Natural competence for genetic transformation in S. pneumoniae plays an important role in aiding pathogenicity and it is the best-characterized feature to acquire antimicrobial resistance genes by a frequent process of recombination. In S. pneumoniae, competence, along with virulence factor production, is controlled by a cell-density communication mechanism termed the competence regulon. In this review, we present the recent advances in the development of alternative methods to attenuate the pathogenicity of S. pneumoniae by targeting the various stages of the non-essential competence regulon communication system. We mainly focus on new developments related to competitively intercepting the competence regulon signaling through the introduction of promising dominant-negative Competence Stimulating Peptide (dnCSP) scaffolds. We also discuss recent reports on antibiotics that can block CSP export by disturbing the proton motive force (PMF) across the membrane and various ways to control the pneumococcal pathogenicity by activating the counter signaling circuit and targeting the pneumococcal proteome." @default.
- W3126989464 created "2021-02-15" @default.
- W3126989464 creator A5035831977 @default.
- W3126989464 creator A5070074639 @default.
- W3126989464 date "2021-02-04" @default.
- W3126989464 modified "2023-10-18" @default.
- W3126989464 title "Strategies to attenuate the competence regulon in <scp> <i>Streptococcus pneumoniae</i> </scp>" @default.
- W3126989464 cites W1516582684 @default.
- W3126989464 cites W1590377795 @default.
- W3126989464 cites W1641873288 @default.
- W3126989464 cites W1676539675 @default.
- W3126989464 cites W178951398 @default.
- W3126989464 cites W1850703260 @default.
- W3126989464 cites W1963695230 @default.
- W3126989464 cites W1966137628 @default.
- W3126989464 cites W1968055594 @default.
- W3126989464 cites W1969685924 @default.
- W3126989464 cites W1979477952 @default.
- W3126989464 cites W1979692277 @default.
- W3126989464 cites W1981584833 @default.
- W3126989464 cites W1990289269 @default.
- W3126989464 cites W1995136541 @default.
- W3126989464 cites W2012457803 @default.
- W3126989464 cites W2013437656 @default.
- W3126989464 cites W2020323811 @default.
- W3126989464 cites W2027298376 @default.
- W3126989464 cites W2029047684 @default.
- W3126989464 cites W2030893445 @default.
- W3126989464 cites W2034302623 @default.
- W3126989464 cites W2037409969 @default.
- W3126989464 cites W2042039195 @default.
- W3126989464 cites W2042050496 @default.
- W3126989464 cites W2056174873 @default.
- W3126989464 cites W2056400335 @default.
- W3126989464 cites W2056436891 @default.
- W3126989464 cites W2058127577 @default.
- W3126989464 cites W2059509103 @default.
- W3126989464 cites W2068748028 @default.
- W3126989464 cites W2074568849 @default.
- W3126989464 cites W2074726414 @default.
- W3126989464 cites W2079121293 @default.
- W3126989464 cites W2081491561 @default.
- W3126989464 cites W2081794308 @default.
- W3126989464 cites W2096889654 @default.
- W3126989464 cites W2099399157 @default.
- W3126989464 cites W2101195741 @default.
- W3126989464 cites W2103809436 @default.
- W3126989464 cites W2108281648 @default.
- W3126989464 cites W2112133321 @default.
- W3126989464 cites W2112410133 @default.
- W3126989464 cites W2113456915 @default.
- W3126989464 cites W2118343455 @default.
- W3126989464 cites W2122419967 @default.
- W3126989464 cites W2124219105 @default.
- W3126989464 cites W2128912763 @default.
- W3126989464 cites W2129453055 @default.
- W3126989464 cites W2130515089 @default.
- W3126989464 cites W2139741901 @default.
- W3126989464 cites W2142774438 @default.
- W3126989464 cites W2145435157 @default.
- W3126989464 cites W2146401071 @default.
- W3126989464 cites W2148576186 @default.
- W3126989464 cites W2157819951 @default.
- W3126989464 cites W2159638147 @default.
- W3126989464 cites W2164033870 @default.
- W3126989464 cites W2170257321 @default.
- W3126989464 cites W2341199367 @default.
- W3126989464 cites W2465746813 @default.
- W3126989464 cites W2496356273 @default.
- W3126989464 cites W2522547182 @default.
- W3126989464 cites W2556738030 @default.
- W3126989464 cites W2590191504 @default.
- W3126989464 cites W2615232728 @default.
- W3126989464 cites W2618154477 @default.
- W3126989464 cites W2759675246 @default.
- W3126989464 cites W2768477427 @default.
- W3126989464 cites W2802690825 @default.
- W3126989464 cites W2802913761 @default.
- W3126989464 cites W2805581185 @default.
- W3126989464 cites W2808668519 @default.
- W3126989464 cites W2810588624 @default.
- W3126989464 cites W2851397147 @default.
- W3126989464 cites W2884284911 @default.
- W3126989464 cites W2888137175 @default.
- W3126989464 cites W2891062112 @default.
- W3126989464 cites W2897102188 @default.
- W3126989464 cites W2927163446 @default.
- W3126989464 cites W2943547349 @default.
- W3126989464 cites W2946641059 @default.
- W3126989464 cites W2952476592 @default.
- W3126989464 cites W2952655800 @default.
- W3126989464 cites W2956209150 @default.
- W3126989464 cites W2967948963 @default.
- W3126989464 cites W2972311639 @default.
- W3126989464 cites W2989135569 @default.
- W3126989464 cites W2999928323 @default.
- W3126989464 cites W3009289963 @default.
- W3126989464 cites W3016180176 @default.
- W3126989464 cites W3028874811 @default.
- W3126989464 cites W3082623535 @default.