FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126996420> ?p ?o ?g. }

• W3126996420 abstract "Airway hydration and ciliary function are critical to airway homeostasis and dysregulated in chronic obstructive pulmonary disease (COPD), which is impacted by cigarette smoking and has no therapeutic options. We utilized a high-copy cDNA library genetic selection approach in the amoeba Dictyostelium discoideum to identify genetic protectors to cigarette smoke. Members of the mitochondrial ADP/ATP transporter family adenine nucleotide translocase (ANT) are protective against cigarette smoke in Dictyostelium and human bronchial epithelial cells. Gene expression of ANT2 is reduced in lung tissue from COPD patients and in a mouse smoking model, and overexpression of ANT1 and ANT2 resulted in enhanced oxidative respiration and ATP flux. In addition to the presence of ANT proteins in the mitochondria, they reside at the plasma membrane in airway epithelial cells and regulate airway homeostasis. ANT2 overexpression stimulates airway surface hydration by ATP and maintains ciliary beating after exposure to cigarette smoke, both of which are key functions of the airway. Our study highlights a potential for upregulation of ANT proteins and/or of their agonists in the protection from dysfunctional mitochondrial metabolism, airway hydration and ciliary motility in COPD.This article has an associated First Person interview with the first author of the paper." @default.
• W3126996420 created "2021-02-15" @default.
• W3126996420 creator A5004842912 @default.
• W3126996420 creator A5005178802 @default.
• W3126996420 creator A5005437487 @default.
• W3126996420 creator A5010567054 @default.
• W3126996420 creator A5042031961 @default.
• W3126996420 creator A5044421960 @default.
• W3126996420 creator A5051305516 @default.
• W3126996420 creator A5064925019 @default.
• W3126996420 creator A5072218107 @default.
• W3126996420 creator A5079450329 @default.
• W3126996420 creator A5084896731 @default.
• W3126996420 creator A5085372023 @default.
• W3126996420 date "2021-02-15" @default.
• W3126996420 modified "2023-10-01" @default.
• W3126996420 title "Adenine nucleotide translocase regulates airway epithelial metabolism, surface hydration and ciliary function" @default.
• W3126996420 cites W122888153 @default.
• W3126996420 cites W1963699887 @default.
• W3126996420 cites W1969668718 @default.
• W3126996420 cites W1987751707 @default.
• W3126996420 cites W1990462225 @default.
• W3126996420 cites W1998224383 @default.
• W3126996420 cites W2005574929 @default.
• W3126996420 cites W2006104784 @default.
• W3126996420 cites W2017519756 @default.
• W3126996420 cites W2028175803 @default.
• W3126996420 cites W2030966943 @default.
• W3126996420 cites W2032085358 @default.
• W3126996420 cites W2048506983 @default.
• W3126996420 cites W2051150868 @default.
• W3126996420 cites W2051828034 @default.
• W3126996420 cites W2067813593 @default.
• W3126996420 cites W2069004519 @default.
• W3126996420 cites W2070330056 @default.
• W3126996420 cites W2070649129 @default.
• W3126996420 cites W2071334288 @default.
• W3126996420 cites W2077879961 @default.
• W3126996420 cites W2080619896 @default.
• W3126996420 cites W2080849796 @default.
• W3126996420 cites W2084947365 @default.
• W3126996420 cites W2091751789 @default.
• W3126996420 cites W2099969611 @default.
• W3126996420 cites W2101976092 @default.
• W3126996420 cites W2110663020 @default.
• W3126996420 cites W2115464612 @default.
• W3126996420 cites W2127951128 @default.
• W3126996420 cites W2139200038 @default.
• W3126996420 cites W2140721790 @default.
• W3126996420 cites W2142151501 @default.
• W3126996420 cites W2143060159 @default.
• W3126996420 cites W2149504196 @default.
• W3126996420 cites W2152205575 @default.
• W3126996420 cites W2154409238 @default.
• W3126996420 cites W2156118158 @default.
• W3126996420 cites W2157250831 @default.
• W3126996420 cites W2162308005 @default.
• W3126996420 cites W2164441020 @default.
• W3126996420 cites W2227146331 @default.
• W3126996420 cites W2311203695 @default.
• W3126996420 cites W2320721555 @default.
• W3126996420 cites W2338941232 @default.
• W3126996420 cites W2344717682 @default.
• W3126996420 cites W2606515338 @default.
• W3126996420 cites W2613801133 @default.
• W3126996420 cites W2805652773 @default.
• W3126996420 cites W2901847109 @default.
• W3126996420 cites W2916869320 @default.
• W3126996420 cites W2980489405 @default.
• W3126996420 cites W3133907395 @default.
• W3126996420 cites W4211263216 @default.
• W3126996420 cites W4238744959 @default.
• W3126996420 cites W626038165 @default.
• W3126996420 cites W69413871 @default.
• W3126996420 doi "https://doi.org/10.1242/jcs.257162" @default.
• W3126996420 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7929926" @default.
• W3126996420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33526710" @default.
• W3126996420 hasPublicationYear "2021" @default.
• W3126996420 type Work @default.
• W3126996420 sameAs 3126996420 @default.
• W3126996420 citedByCount "15" @default.
• W3126996420 countsByYear W31269964202021 @default.
• W3126996420 countsByYear W31269964202022 @default.
• W3126996420 countsByYear W31269964202023 @default.
• W3126996420 crossrefType "journal-article" @default.
• W3126996420 hasAuthorship W3126996420A5004842912 @default.
• W3126996420 hasAuthorship W3126996420A5005178802 @default.
• W3126996420 hasAuthorship W3126996420A5005437487 @default.
• W3126996420 hasAuthorship W3126996420A5010567054 @default.
• W3126996420 hasAuthorship W3126996420A5042031961 @default.
• W3126996420 hasAuthorship W3126996420A5044421960 @default.
• W3126996420 hasAuthorship W3126996420A5051305516 @default.
• W3126996420 hasAuthorship W3126996420A5064925019 @default.
• W3126996420 hasAuthorship W3126996420A5072218107 @default.
• W3126996420 hasAuthorship W3126996420A5079450329 @default.
• W3126996420 hasAuthorship W3126996420A5084896731 @default.
• W3126996420 hasAuthorship W3126996420A5085372023 @default.
• W3126996420 hasBestOaLocation W31269964201 @default.
• W3126996420 hasConcept C105922876 @default.
• W3126996420 hasConcept C126322002 @default.

• next