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• W3127014745 abstract "Significance Cell–cell junctions are essential components in multicellular structures and often experience strains of different magnitudes and rates. However, their mechanical behavior is currently underexplored due to the lack of techniques to quantitatively characterize junctional stress–strain relationships. We developed a polymeric microstructure to strain the mutual junction of a single cell pair while simultaneously recording the junction stress and observed previously unseen strain-rate–dependent junction responses. We showed that cytoskeleton growth could relax the stress buildup and prevent junction failure at low strain rates, while high strain rates led to synchronized junction failures at remarkably large strains (over 200%). We expect this platform and our biophysical understanding to form the foundation for the rate-dependent mechanics of cell–cell junctions." @default.
• W3127014745 created "2021-02-15" @default.
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• W3127014745 date "2021-02-02" @default.
• W3127014745 modified "2023-09-27" @default.
• W3127014745 title "Characterization of the strain-rate–dependent mechanical response of single cell–cell junctions" @default.
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• W3127014745 doi "https://doi.org/10.1073/pnas.2019347118" @default.
• W3127014745 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7896335" @default.
• W3127014745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33531347" @default.

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