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- W3127029004 abstract "A macroscopic theory for describing cellular states during steady growth is presented, based on the consistency between cellular growth and molecular replication, as well as the robustness of phenotypes against perturbations. Adaptive changes in high-dimensional phenotypes were shown to be restricted within a low-dimensional slow manifold, from which a macroscopic law for cellular states was derived, which was confirmed by adaptation experiments on bacteria under stress. Next, the theory was extended to phenotypic evolution, leading to proportionality between phenotypic responses against genetic evolution and environmental adaptation. The link between robustness to noise and mutation, as a result of robustness in developmental dynamics to perturbations, showed proportionality between phenotypic plasticity by genetic changes and by environmental noise. Accordingly, directionality and constraint in phenotypic evolution were formulated in terms of phenotypic fluctuation and the response against environmental change. The evolutionary relevance of slow modes in controlling high-dimensional phenotypes is discussed." @default.
- W3127029004 created "2021-02-15" @default.
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- W3127029004 date "2021-01-01" @default.
- W3127029004 modified "2023-09-30" @default.
- W3127029004 title "Direction and Constraint in Phenotypic Evolution: Dimension Reduction and Global Proportionality in Phenotype Fluctuation and Responses" @default.
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