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• W3127036224 abstract "Cortical bone microstructure deficits may increase fracture risk in individuals with cardiovascular disease and diabetes. High resolution peripheral quantitative computed tomography (HR-pQCT) enables in vivo microstructure characterization but is limited in its ability to visualize important biological features. We conducted histological analyses and HR-pQCT imaging of distal tibia bone samples from 6 donors with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2D). Histology but not HR-pQCT identified previously undocumented morphopathological deficits that may contribute to cortical bone fragility. These observations may provide guidance for improved HR-pQCT microstructural characterization as well as insight into mechanisms of cortical bone degradation." @default.
• W3127036224 created "2021-02-15" @default.
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• W3127036224 date "2021-06-01" @default.
• W3127036224 modified "2023-09-30" @default.
• W3127036224 title "Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions" @default.
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• W3127036224 doi "https://doi.org/10.1016/j.medntd.2021.100062" @default.
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