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• W3127063016 abstract "Research priority guidelines highlight the need for examining the dose components of palliative care (PC) interventions, such as intervention adherence and completion rates, that contribute to optimal outcomes.Examine the dose effect of PC intervention completion vs. noncompletion on quality of life (QoL) and healthcare use in patients with advanced heart failure (HF) over 32 weeks.Secondary analysis of the ENABLE CHF-PC intervention trial for patients with New York Heart Association (NYHA) Class III/IV HF. Completers defined as completing a single, in-person outpatient palliative care consultation (OPCC) plus 6 weekly, PC nurse coach-led telehealth sessions. Non-completers were defined as either not attending the OPCC or completing <6 telehealth sessions. Outcome variables were QoL and healthcare resource use (hospital days; emergency department visits). Mixed models were used to model dose effects for completers vs noncompleters over 32 weeks.Of 208 intervention group participants, 81 (38.9%) were classified as completers with a mean age of 64.6 years; 72.8% were urban-dwelling; 92.5% had NYHA Class III HF. 'Completers' vs. non-completers groups were well-balanced at baseline; however noncompleters did report higher anxiety (6.0 vs 7.0, P < 0.05, d = 0.28). Moderate, clinically significant, improved QoL differences were found at 16 weeks in completers vs. non-completers (between-group difference: -9.71 (3.18), d = 0.47, P = 0.002) but not healthcare use.Higher intervention completion rates of an early PC intervention was associated with QoL improvements in patients with advanced HF. Future work should focus on identifying the most efficacious dose of intervention components and increasing adherence to them.ClinicalTrials.gov Identifier: NCT02505425." @default.
• W3127063016 created "2021-02-15" @default.
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• W3127063016 date "2021-09-01" @default.
• W3127063016 modified "2023-09-30" @default.
• W3127063016 title "Examining Adherence and Dose Effect of an Early Palliative Care Intervention for Advanced Heart Failure Patients" @default.
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• W3127063016 doi "https://doi.org/10.1016/j.jpainsymman.2021.01.136" @default.
• W3127063016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8339177" @default.
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