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• W3127116131 abstract "ABSTRACT Background During development, complex organ patterns emerge through the precise temporal and spatial specification of different cell types. On an evolutionary timescale, these patterns can change, resulting in morphological diversification. It is generally believed that homologous anatomical structures are built – largely – by homologous cell types. However, whether a common evolutionary origin of such cell types is always reflected in the conservation of their intrinsic transcriptional specification programs is less clear. Results Here, using a paradigm of morphological diversification, the tetrapod limb, and singlecell RNA-sequencing data from two distantly related species, chicken and mouse, we assessed the transcriptional dynamics of homologous cell types during embryonic patterning. We developed a user-friendly bioinformatics workflow to detect gene co-expression modules and test for their conservation across developmental stages and species boundaries. Using mouse limb data as reference, we identified 19 gene co-expression modules with varying tissue or cell type-restricted activities. Testing for co-expression conservation revealed modules with high evolutionary turnover, while others seemed maintained – to different degrees, in module make-up, density or connectivity – over developmental and evolutionary timescales. Conclusions We present an approach to identify evolutionary and developmental dynamics in gene co-expression modules during patterning-relevant stages of homologous cell type specification." @default.
• W3127116131 created "2021-02-15" @default.
• W3127116131 creator A5026934867 @default.
• W3127116131 creator A5043791173 @default.
• W3127116131 date "2021-02-10" @default.
• W3127116131 modified "2023-09-23" @default.
• W3127116131 title "Assessing evolutionary and developmental transcriptome dynamics in homologous cell types" @default.
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• W3127116131 doi "https://doi.org/10.1101/2021.02.09.430383" @default.
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