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• W3127155476 abstract "Timely and precise delivery of the endosomal Toll-like receptors (TLRs) to the ligand recognition site is a critical event in mounting an effective antimicrobial immune response, however, the same TLRs should maintain the delicate balance of avoiding recognition of self-nucleic acids. Such sensing is widely known to start from endosomal compartments, but recently enough evidence has accumulated supporting the idea that TLR-mediated signaling pathways originating in the cell membrane may be engaged in various cells due to differential expression and distribution of the endosomal TLRs. Therefore, the presence of endosomal TLRs on the cell surface could benefit the host responses in certain cell types and/or organs. Although not fully understood why, TLR3, TLR7, and TLR9 may occur both in the cell membrane and intracellularly, and it seems that activation of the immune response can be initiated concurrently from these two sites in the cell. Furthermore, various forms of endosomal TLRs may be transported to the cell membrane, indicating that this may be a normal process orchestrated by cysteine proteases—cathepsins. Among the endosomal TLRs, TLR3 belongs to the evolutionary distinct group and engages a different protein adapter in the signaling cascade. The differently glycosylated forms of TLR3 are transported by UNC93B1 to the cell membrane, unlike TLR7, TLR8, and TLR9. The aim of this review is to reconcile various views on the cell surface positioning of endosomal TLRs and add perspective to the implication of such receptor localization on their function, with special attention to TLR3. Cell membrane-localized TLR3, TLR7, and TLR9 may contribute to endosomal TLR-mediated inflammatory signaling pathways. Dissecting this signaling axis may serve to better understand mechanisms influencing endosomal TLR-mediated inflammation, thus determine whether it is a necessity for immune response or simply a circumstantial superfluous duplication, with other consequences on immune response." @default.
• W3127155476 created "2021-02-15" @default.
• W3127155476 creator A5041486037 @default.
• W3127155476 creator A5065611632 @default.
• W3127155476 creator A5083154102 @default.
• W3127155476 date "2021-02-01" @default.
• W3127155476 modified "2023-10-18" @default.
• W3127155476 title "Cell Surface Expression of Endosomal Toll-Like Receptors—A Necessity or a Superfluous Duplication?" @default.
• W3127155476 cites W1494706121 @default.
• W3127155476 cites W1525925511 @default.
• W3127155476 cites W1537388372 @default.
• W3127155476 cites W1584834036 @default.
• W3127155476 cites W1598171376 @default.
• W3127155476 cites W1598802044 @default.
• W3127155476 cites W1623115463 @default.
• W3127155476 cites W1667782349 @default.
• W3127155476 cites W1872552981 @default.
• W3127155476 cites W1929815480 @default.
• W3127155476 cites W1964351757 @default.
• W3127155476 cites W1969354039 @default.
• W3127155476 cites W1970291282 @default.
• W3127155476 cites W1981498390 @default.
• W3127155476 cites W1985030583 @default.
• W3127155476 cites W1987410025 @default.
• W3127155476 cites W1987925713 @default.
• W3127155476 cites W1988299037 @default.
• W3127155476 cites W1988952405 @default.
• W3127155476 cites W1990872903 @default.
• W3127155476 cites W1998211335 @default.
• W3127155476 cites W2001747259 @default.
• W3127155476 cites W2001757395 @default.
• W3127155476 cites W2001904356 @default.
• W3127155476 cites W2004076358 @default.
• W3127155476 cites W2004726009 @default.
• W3127155476 cites W2007148556 @default.
• W3127155476 cites W2009392385 @default.
• W3127155476 cites W2010846919 @default.
• W3127155476 cites W2014056557 @default.
• W3127155476 cites W2022680502 @default.
• W3127155476 cites W2022947195 @default.
• W3127155476 cites W2022970081 @default.
• W3127155476 cites W2025980739 @default.
• W3127155476 cites W2030665562 @default.
• W3127155476 cites W2030994794 @default.
• W3127155476 cites W2035253913 @default.
• W3127155476 cites W2036807187 @default.
• W3127155476 cites W2038829635 @default.
• W3127155476 cites W2039854966 @default.
• W3127155476 cites W2040344368 @default.
• W3127155476 cites W2046750158 @default.
• W3127155476 cites W2048067575 @default.
• W3127155476 cites W2048797077 @default.
• W3127155476 cites W2049449151 @default.
• W3127155476 cites W2049874360 @default.
• W3127155476 cites W2053283871 @default.
• W3127155476 cites W2055374064 @default.
• W3127155476 cites W2055527896 @default.
• W3127155476 cites W2055653501 @default.
• W3127155476 cites W2056423038 @default.
• W3127155476 cites W2057183023 @default.
• W3127155476 cites W2058059173 @default.
• W3127155476 cites W2058229730 @default.
• W3127155476 cites W2060351820 @default.
• W3127155476 cites W2061203855 @default.
• W3127155476 cites W2062267695 @default.
• W3127155476 cites W2065276143 @default.
• W3127155476 cites W2068923658 @default.
• W3127155476 cites W2068975016 @default.
• W3127155476 cites W2070131223 @default.
• W3127155476 cites W2074472721 @default.
• W3127155476 cites W2074937428 @default.
• W3127155476 cites W2075383643 @default.
• W3127155476 cites W2077486035 @default.
• W3127155476 cites W2079776221 @default.
• W3127155476 cites W2079946840 @default.
• W3127155476 cites W2080399344 @default.
• W3127155476 cites W2081342442 @default.
• W3127155476 cites W2084603524 @default.
• W3127155476 cites W2086973624 @default.
• W3127155476 cites W2087032228 @default.
• W3127155476 cites W2087162322 @default.
• W3127155476 cites W2088884484 @default.
• W3127155476 cites W2091817471 @default.
• W3127155476 cites W2092733738 @default.
• W3127155476 cites W2094746130 @default.
• W3127155476 cites W2097217535 @default.
• W3127155476 cites W2100889365 @default.
• W3127155476 cites W2103287192 @default.
• W3127155476 cites W2103681939 @default.
• W3127155476 cites W2104630342 @default.
• W3127155476 cites W2107182434 @default.
• W3127155476 cites W2109491705 @default.
• W3127155476 cites W2110223162 @default.
• W3127155476 cites W2114741192 @default.
• W3127155476 cites W2117200779 @default.
• W3127155476 cites W2117780508 @default.
• W3127155476 cites W2117963002 @default.
• W3127155476 cites W2120266115 @default.
• W3127155476 cites W2122065046 @default.
• W3127155476 cites W2125491088 @default.

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