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• W3127187980 abstract "Integrins are essential membrane proteins that provide a tightly regulated link between the extracellular matrix and the intracellular cytoskeletal network. These cell surface proteins are composed of a non-covalently bound α chain and β chain. The leukocyte-specific complement receptor 3 (CR3, αMβ2, CD11b/CD18) and complement receptor 4 (CR4, αXβ2, CD11c/CD18) belong to the family of β2-integrins. These receptors bind multiple ligands like iC3b, ICAMs, fibrinogen or LPS, thus allowing them to partake in phagocytosis, cellular adhesion, extracellular matrix rearrangement and migration. CR3 and CR4 were generally expected to mediate identical functions due to their structural homology, overlapping ligand specificity and parallel expression on human phagocytes. Despite their similarities, the expression level and function of these receptors differ in a cell-type-specific manner, both under physiological and inflammatory conditions.We investigated comprehensively the individual role of CR3 and CR4 in various functions of human phagocytes, and we proved that there is a division of labour between these two receptors. In this review, I will summarize our current knowledge about this area." @default.
• W3127187980 created "2021-02-15" @default.
• W3127187980 creator A5047621400 @default.
• W3127187980 date "2021-02-06" @default.
• W3127187980 modified "2023-10-07" @default.
• W3127187980 title "Biologia Futura: stories about the functions of β2-integrins in human phagocytes" @default.
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• W3127187980 doi "https://doi.org/10.1007/s42977-020-00063-z" @default.
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