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- W3127191844 abstract "Solid tumors are dependent on vascularization for their growth. The hypoxic, stiff, and pro-angiogenic tumor microenvironment induces angiogenesis, giving rise to an immature, proliferative, and permeable vasculature. The tumor vessels promote tumor metastasis and complicate delivery of anti-cancer therapies. In many types of tumors, YAP/TAZ activation is correlated with increased levels of angiogenesis. In addition, endothelial YAP/TAZ activation is important for the formation of new blood and lymphatic vessels during development. Oncogenic activation of YAP/TAZ in tumor cell growth and invasion has been studied in great detail, however the role of YAP/TAZ within the tumor endothelium remains insufficiently understood, which complicates therapeutic strategies aimed at targeting YAP/TAZ in cancer. Here, we overview the upstream signals from the tumor microenvironment that control endothelial YAP/TAZ activation and explore the role of their downstream targets in driving tumor angiogenesis. We further discuss the potential for anti-cancer treatments and vascular normalization strategies to improve tumor therapies." @default.
- W3127191844 created "2021-02-15" @default.
- W3127191844 creator A5016611690 @default.
- W3127191844 creator A5050401249 @default.
- W3127191844 creator A5068007728 @default.
- W3127191844 creator A5084610580 @default.
- W3127191844 date "2021-02-04" @default.
- W3127191844 modified "2023-10-04" @default.
- W3127191844 title "Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature" @default.
- W3127191844 cites W1429913920 @default.
- W3127191844 cites W1486264823 @default.
- W3127191844 cites W1497165801 @default.
- W3127191844 cites W1539804860 @default.
- W3127191844 cites W1545165945 @default.
- W3127191844 cites W1573363574 @default.
- W3127191844 cites W1603230122 @default.
- W3127191844 cites W1710605776 @default.
- W3127191844 cites W1772965091 @default.
- W3127191844 cites W1787824584 @default.
- W3127191844 cites W1794354274 @default.
- W3127191844 cites W1863585495 @default.
- W3127191844 cites W1866104439 @default.
- W3127191844 cites W1888543545 @default.
- W3127191844 cites W1907833971 @default.
- W3127191844 cites W1941703300 @default.
- W3127191844 cites W1943570487 @default.
- W3127191844 cites W1953357409 @default.
- W3127191844 cites W1965362233 @default.
- W3127191844 cites W1965661842 @default.
- W3127191844 cites W1967720639 @default.
- W3127191844 cites W1970016838 @default.
- W3127191844 cites W1971010914 @default.
- W3127191844 cites W1971844501 @default.
- W3127191844 cites W1974307668 @default.
- W3127191844 cites W1975216289 @default.
- W3127191844 cites W1976094219 @default.
- W3127191844 cites W1976474458 @default.
- W3127191844 cites W1977587080 @default.
- W3127191844 cites W1978157267 @default.
- W3127191844 cites W1978206983 @default.
- W3127191844 cites W1979581862 @default.
- W3127191844 cites W1980819464 @default.
- W3127191844 cites W1980932859 @default.
- W3127191844 cites W1982030062 @default.
- W3127191844 cites W1982498121 @default.
- W3127191844 cites W1983392133 @default.
- W3127191844 cites W1984350114 @default.
- W3127191844 cites W1984383995 @default.
- W3127191844 cites W1985500381 @default.
- W3127191844 cites W1985804036 @default.
- W3127191844 cites W1987213190 @default.
- W3127191844 cites W1987263161 @default.
- W3127191844 cites W1988193334 @default.
- W3127191844 cites W1988971910 @default.
- W3127191844 cites W1992092426 @default.
- W3127191844 cites W1992112921 @default.
- W3127191844 cites W1994435105 @default.
- W3127191844 cites W1995160678 @default.
- W3127191844 cites W1995168398 @default.
- W3127191844 cites W1995798600 @default.
- W3127191844 cites W1998187102 @default.
- W3127191844 cites W1998777645 @default.
- W3127191844 cites W2000102677 @default.
- W3127191844 cites W2000502243 @default.
- W3127191844 cites W2004480757 @default.
- W3127191844 cites W2005055996 @default.
- W3127191844 cites W2007897471 @default.
- W3127191844 cites W2008053177 @default.
- W3127191844 cites W2011121500 @default.
- W3127191844 cites W2011806880 @default.
- W3127191844 cites W2012726972 @default.
- W3127191844 cites W2015446910 @default.
- W3127191844 cites W2016126437 @default.
- W3127191844 cites W2016642619 @default.
- W3127191844 cites W2016672123 @default.
- W3127191844 cites W2017322644 @default.
- W3127191844 cites W2018058518 @default.
- W3127191844 cites W2018991117 @default.
- W3127191844 cites W2022540958 @default.
- W3127191844 cites W2023404925 @default.
- W3127191844 cites W2024131284 @default.
- W3127191844 cites W2024903578 @default.
- W3127191844 cites W2025036947 @default.
- W3127191844 cites W2025879648 @default.
- W3127191844 cites W2027150010 @default.
- W3127191844 cites W2028437938 @default.
- W3127191844 cites W2030537346 @default.
- W3127191844 cites W2030729823 @default.
- W3127191844 cites W2032912914 @default.
- W3127191844 cites W2033998652 @default.
- W3127191844 cites W2035183057 @default.
- W3127191844 cites W2035282407 @default.
- W3127191844 cites W2036447990 @default.
- W3127191844 cites W2037943855 @default.
- W3127191844 cites W2039791984 @default.
- W3127191844 cites W2040430549 @default.
- W3127191844 cites W2040593473 @default.
- W3127191844 cites W2040612938 @default.
- W3127191844 cites W2041299023 @default.
- W3127191844 cites W2041797267 @default.