FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3127200220> ?p ?o ?g. }

• W3127200220 abstract "Abstract The ongoing SARS-CoV-2 pandemic is the third zoonotic coronavirus identified in the last twenty years. Enzootic and epizootic coronaviruses of diverse lineages also pose a significant threat to livestock, as most recently observed for virulent strains of porcine epidemic diarrhea virus (PEDV) and swine acute diarrhea-associated coronavirus (SADS-CoV). Unique to RNA viruses, coronaviruses encode a proofreading exonuclease (ExoN) that lowers point mutation rates to increase the viability of large RNA virus genomes, which comes with the cost of limiting virus adaptation via point mutation. This limitation can be overcome by high rates of recombination that facilitate rapid increases in genetic diversification. To compare dynamics of recombination between related sequences, we developed an open-source computational workflow (IDPlot) to measure nucleotide identity, locate recombination breakpoints, and infer phylogenetic relationships. We analyzed recombination dynamics among three groups of coronaviruses with noteworthy impacts on human health and agriculture: SARSr-CoV, Betacoronavirus-1 , and SADSr-CoV. We found that all three groups undergo recombination with highly diverged viruses from sparsely sampled or undescribed lineages, which can disrupt the inference of phylogenetic relationships. In most cases, no parental origin of recombinant regions could be found in genetic databases, suggesting that much coronavirus diversity remains unknown. These patterns of recombination expand the genetic pool that may contribute to future zoonotic events. Our results also illustrate the limitations of current sampling approaches for anticipating zoonotic threats to human and animal health." @default.
• W3127200220 created "2021-02-15" @default.
• W3127200220 creator A5021107967 @default.
• W3127200220 creator A5038170541 @default.
• W3127200220 creator A5048401073 @default.
• W3127200220 creator A5069784424 @default.
• W3127200220 creator A5082576878 @default.
• W3127200220 date "2021-02-04" @default.
• W3127200220 modified "2023-09-25" @default.
• W3127200220 title "Extensive recombination-driven coronavirus diversification expands the pool of potential pandemic pathogens" @default.
• W3127200220 cites W1933155703 @default.
• W3127200220 cites W1965669216 @default.
• W3127200220 cites W1984963559 @default.
• W3127200220 cites W1987655599 @default.
• W3127200220 cites W2008671763 @default.
• W3127200220 cites W2008811126 @default.
• W3127200220 cites W2017380851 @default.
• W3127200220 cites W2019521351 @default.
• W3127200220 cites W2023913269 @default.
• W3127200220 cites W2031611770 @default.
• W3127200220 cites W2036144053 @default.
• W3127200220 cites W2086693601 @default.
• W3127200220 cites W2099731870 @default.
• W3127200220 cites W2104474203 @default.
• W3127200220 cites W2106814707 @default.
• W3127200220 cites W2112011866 @default.
• W3127200220 cites W2116836732 @default.
• W3127200220 cites W2126428749 @default.
• W3127200220 cites W2127774996 @default.
• W3127200220 cites W2132260239 @default.
• W3127200220 cites W2149133482 @default.
• W3127200220 cites W2152528032 @default.
• W3127200220 cites W2155302934 @default.
• W3127200220 cites W2166867592 @default.
• W3127200220 cites W2255897570 @default.
• W3127200220 cites W2280321019 @default.
• W3127200220 cites W2285897784 @default.
• W3127200220 cites W2318113373 @default.
• W3127200220 cites W2508433652 @default.
• W3127200220 cites W2513547424 @default.
• W3127200220 cites W2576706040 @default.
• W3127200220 cites W2605897695 @default.
• W3127200220 cites W2726784030 @default.
• W3127200220 cites W2762957326 @default.
• W3127200220 cites W2773680311 @default.
• W3127200220 cites W2775086803 @default.
• W3127200220 cites W2792545913 @default.
• W3127200220 cites W2794573360 @default.
• W3127200220 cites W2798913987 @default.
• W3127200220 cites W2891121035 @default.
• W3127200220 cites W2894950287 @default.
• W3127200220 cites W2902822103 @default.
• W3127200220 cites W2952733287 @default.
• W3127200220 cites W2952739713 @default.
• W3127200220 cites W2974693537 @default.
• W3127200220 cites W2976288913 @default.
• W3127200220 cites W3004280078 @default.
• W3127200220 cites W3009906937 @default.
• W3127200220 cites W3013152614 @default.
• W3127200220 cites W3021655800 @default.
• W3127200220 cites W3022428749 @default.
• W3127200220 cites W3023560309 @default.
• W3127200220 cites W3046218112 @default.
• W3127200220 cites W3049233984 @default.
• W3127200220 cites W3092011752 @default.
• W3127200220 cites W311927316 @default.
• W3127200220 doi "https://doi.org/10.1101/2021.02.03.429646" @default.
• W3127200220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7872347" @default.
• W3127200220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33564759" @default.
• W3127200220 hasPublicationYear "2021" @default.
• W3127200220 type Work @default.
• W3127200220 sameAs 3127200220 @default.
• W3127200220 citedByCount "17" @default.
• W3127200220 countsByYear W31272002202021 @default.
• W3127200220 countsByYear W31272002202022 @default.
• W3127200220 crossrefType "posted-content" @default.
• W3127200220 hasAuthorship W3127200220A5021107967 @default.
• W3127200220 hasAuthorship W3127200220A5038170541 @default.
• W3127200220 hasAuthorship W3127200220A5048401073 @default.
• W3127200220 hasAuthorship W3127200220A5069784424 @default.
• W3127200220 hasAuthorship W3127200220A5082576878 @default.
• W3127200220 hasBestOaLocation W31272002201 @default.
• W3127200220 hasConcept C104317684 @default.
• W3127200220 hasConcept C141231307 @default.
• W3127200220 hasConcept C142724271 @default.
• W3127200220 hasConcept C156695909 @default.
• W3127200220 hasConcept C159047783 @default.
• W3127200220 hasConcept C193252679 @default.
• W3127200220 hasConcept C2522874641 @default.
• W3127200220 hasConcept C2775862345 @default.
• W3127200220 hasConcept C2777648638 @default.
• W3127200220 hasConcept C2779134260 @default.
• W3127200220 hasConcept C3008058167 @default.
• W3127200220 hasConcept C524204448 @default.
• W3127200220 hasConcept C54355233 @default.
• W3127200220 hasConcept C71924100 @default.
• W3127200220 hasConcept C78458016 @default.
• W3127200220 hasConcept C86803240 @default.
• W3127200220 hasConcept C90132467 @default.
• W3127200220 hasConceptScore W3127200220C104317684 @default.

• next