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- W3127287238 abstract "Abstract ParaHydrogen induced polarization (PHIP) is an efficient and cost-effective hyperpolarization method, but its application to biological investigations has been hampered, so far, due to chemical challenges. PHIP is obtained by means of the addition of hydrogen, enriched in the para-spin isomer, to an unsaturated substrate. Both hydrogen atoms must be transferred to the same substrate, in a pairwise manner, by a suitable hydrogenation catalyst; therefore, a de-hydrogenated precursor of the target molecule is necessary. This has strongly limited the number of parahydrogen polarized substrates. The non-hydrogenative approach brilliantly circumvents this central issue, but has not been translated to in-vivo yet. Recent advancements in hydrogenative PHIP (h-PHIP) considerably widened the possibility to hyperpolarize metabolites and, in this review, we will focus on substrates that have been obtained by means of this method and used in vivo. Attention will also be paid to the requirements that must be met and on the issues that have still to be tackled to obtain further improvements and to push PHIP substrates in biological applications." @default.
- W3127287238 created "2021-02-15" @default.
- W3127287238 creator A5014689134 @default.
- W3127287238 creator A5037194437 @default.
- W3127287238 creator A5038724542 @default.
- W3127287238 creator A5039763901 @default.
- W3127287238 date "2021-02-01" @default.
- W3127287238 modified "2023-10-16" @default.
- W3127287238 title "Hydrogenative-PHIP polarized metabolites for biological studies" @default.
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