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- W3127332546 abstract "The administration of meropenem in hospitalized patients is restricted when a suspected penicillin allergy is present. This leads to the use of second-line treatments that increase the risk of antibiotic resistances and healthcare costs. We aimed to study the utility of a bedside meropenem allergy workout in these patients. A case series of 182 patients in a hospital setting with medical histories precluding the administration of meropenem when it would normally be considered a first-line treatment. Patients underwent a bedside allergological workout for two hours, including skin testing and a drug challenge test (DCT), with meropenem. In 180 out of 182 (99%) patients, the initial avoidance of meropenem was based on a suspected history of penicillin-allergy, while two patients reported a history of an adverse reaction to meropenem. An allergological workout of beta-lactam allergies was accomplished in 43 out of the 180 patients labelled as suspected penicillin allergy, which confirmed reactivity to penicillin (7 patients), amoxicillin (7 patients), piperacillin/tazobactam (6 patients) and penicillin, amoxicillin and ampicillin (2 patients). In 7 out of 182 (4%) patients, a meropenem allergy was confirmed by a positive result in intradermal test (5 patients) or during the DCT (2 patients). Additionally, two patients also had an allergy to penicillin, one to penicillin and amoxicillin and two to piperacillin/tazobactam. A rapid, simple and safe bedside allergy study permitted the administration of meropenem successfully in more than 9 out of 10 patients. Interestingly, most of the patients additionally presented an allergy to other beta-lactams, including piperacillin/tazobactam." @default.
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- W3127332546 date "2021-02-01" @default.
- W3127332546 modified "2023-09-27" @default.
- W3127332546 title "Needlessly Avoiding Meropenem Use In Hospitalized Patients" @default.
- W3127332546 doi "https://doi.org/10.1016/j.jaci.2020.12.096" @default.
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