FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3127367047> ?p ?o ?g. }

• W3127367047 endingPage "1080" @default.
• W3127367047 startingPage "1080" @default.
• W3127367047 abstract "Observational studies suggest that low vitamin D levels are associated with increased risk and severity of COVID-19 infection. We used Mendelian randomization (MR) to investigate causality of the vitamin D—COVID-19 association. We constructed a biologically plausible genetic instrument for serum vitamin D based on replicated genome-wide significant variants in genes related to vitamin D metabolism, and evaluated the validity of the genetic instrument in COVID-19 risk subgroups in the UK Biobank. We then performed two sample MR using publically available summary data for the association of the genetic instrument with serum vitamin D in the UK Biobank and with COVID-19 outcomes, including infection, severe respiratory infection, and hospitalization, in the COVID-19 Host Genetics Initiative. We used the inverse-variance weighted MR method for all analyses. We found little to no evidence for an effect of genetically predicted serum vitamin D on susceptibility to or severity of COVID-19 infection. The odds ratio per standard deviation increase in genetically predicted serum vitamin D were: 1.04 (95% confidence interval 0.92 to 1.18) for any COVID-19 infection vs. population controls, 1.05 (0.84–1.31) for hospitalized COVID-19 vs. population controls, 0.96 (0.64 to 1.43) for severe respiratory COVID-19 vs. population controls, 1.15 (0.99 to 1.35) for COVID-19 positive vs. COVID-19 negative and, 1.44 (0.75 to 2.78) for hospitalized COVID-19 vs. non-hospitalized COVID-19. Results were similar in analyses where the genetic instrument included all variants with genome-wide significant associations with serum vitamin D (i.e., including variants with no known relationship to vitamin D metabolism) and where the genetic instrument was for risk of vitamin D deficiency. Our results suggest that unconfounded, long-term differences in vitamin D status do not causally affect susceptibility to and severity of COVID-19 infection. These findings are consistent with results of a recently published MR study and suggest that associations seen in observational studies may be driven by confounding. Future directions include extending this work to non-European ancestry populations and high-risk populations, for example persons with comorbid disease. NIDDK, NHLBI and NHGRI of the NIH." @default.
• W3127367047 created "2021-02-15" @default.
• W3127367047 creator A5006834944 @default.
• W3127367047 creator A5010195745 @default.
• W3127367047 creator A5019653549 @default.
• W3127367047 creator A5040316492 @default.
• W3127367047 creator A5067632644 @default.
• W3127367047 date "2021-06-01" @default.
• W3127367047 modified "2023-10-01" @default.
• W3127367047 title "Genetically Predicted Serum Vitamin D and COVID-19: A Mendelian Randomization Study" @default.
• W3127367047 doi "https://doi.org/10.1093/cdn/nzab053_073" @default.
• W3127367047 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8180643" @default.
• W3127367047 hasPublicationYear "2021" @default.
• W3127367047 type Work @default.
• W3127367047 sameAs 3127367047 @default.
• W3127367047 citedByCount "2" @default.
• W3127367047 countsByYear W31273670472021 @default.
• W3127367047 countsByYear W31273670472022 @default.
• W3127367047 crossrefType "journal-article" @default.
• W3127367047 hasAuthorship W3127367047A5006834944 @default.
• W3127367047 hasAuthorship W3127367047A5010195745 @default.
• W3127367047 hasAuthorship W3127367047A5019653549 @default.
• W3127367047 hasAuthorship W3127367047A5040316492 @default.
• W3127367047 hasAuthorship W3127367047A5067632644 @default.
• W3127367047 hasBestOaLocation W31273670471 @default.
• W3127367047 hasConcept C104317684 @default.
• W3127367047 hasConcept C106208931 @default.
• W3127367047 hasConcept C124490489 @default.
• W3127367047 hasConcept C126322002 @default.
• W3127367047 hasConcept C135763542 @default.
• W3127367047 hasConcept C153209595 @default.
• W3127367047 hasConcept C156957248 @default.
• W3127367047 hasConcept C2779901538 @default.
• W3127367047 hasConcept C2908647359 @default.
• W3127367047 hasConcept C2993967602 @default.
• W3127367047 hasConcept C42407357 @default.
• W3127367047 hasConcept C44249647 @default.
• W3127367047 hasConcept C54355233 @default.
• W3127367047 hasConcept C71924100 @default.
• W3127367047 hasConcept C86803240 @default.
• W3127367047 hasConcept C99454951 @default.
• W3127367047 hasConceptScore W3127367047C104317684 @default.
• W3127367047 hasConceptScore W3127367047C106208931 @default.
• W3127367047 hasConceptScore W3127367047C124490489 @default.
• W3127367047 hasConceptScore W3127367047C126322002 @default.
• W3127367047 hasConceptScore W3127367047C135763542 @default.
• W3127367047 hasConceptScore W3127367047C153209595 @default.
• W3127367047 hasConceptScore W3127367047C156957248 @default.
• W3127367047 hasConceptScore W3127367047C2779901538 @default.
• W3127367047 hasConceptScore W3127367047C2908647359 @default.
• W3127367047 hasConceptScore W3127367047C2993967602 @default.
• W3127367047 hasConceptScore W3127367047C42407357 @default.
• W3127367047 hasConceptScore W3127367047C44249647 @default.
• W3127367047 hasConceptScore W3127367047C54355233 @default.
• W3127367047 hasConceptScore W3127367047C71924100 @default.
• W3127367047 hasConceptScore W3127367047C86803240 @default.
• W3127367047 hasConceptScore W3127367047C99454951 @default.
• W3127367047 hasLocation W31273670471 @default.
• W3127367047 hasLocation W31273670472 @default.
• W3127367047 hasLocation W31273670473 @default.
• W3127367047 hasOpenAccess W3127367047 @default.
• W3127367047 hasPrimaryLocation W31273670471 @default.
• W3127367047 hasRelatedWork W2051569221 @default.
• W3127367047 hasRelatedWork W2089973565 @default.
• W3127367047 hasRelatedWork W2183817991 @default.
• W3127367047 hasRelatedWork W2553553016 @default.
• W3127367047 hasRelatedWork W2946612292 @default.
• W3127367047 hasRelatedWork W2952883732 @default.
• W3127367047 hasRelatedWork W4205420791 @default.
• W3127367047 hasRelatedWork W4220909168 @default.
• W3127367047 hasRelatedWork W4306951716 @default.
• W3127367047 hasRelatedWork W4320065076 @default.
• W3127367047 hasVolume "5" @default.
• W3127367047 isParatext "false" @default.
• W3127367047 isRetracted "false" @default.
• W3127367047 magId "3127367047" @default.
• W3127367047 workType "article" @default.