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• W3127375237 abstract "Endothelialization is required to maintain patency in tissue-engineered vascular grafts (TEVGs). Ligand surface functionalization is intended to induce the adhesion and spreading of Endothelial Cells (ECs). ECs surface adhesion occurs through the integrin-ligand interaction. Here, we propose a chemo-mechanical model, using COMSOL Multiphysics 5.5, to study the optimal ligand distribution in order to improve interaction under laminar blood flow. The proposed model elucidates the role of binding forces and flow velocities over cell spreading as a function of the relevant ligand concentration. This model can contribute to optimizing the surface functionalization of TEVGs for promoting successful endothelialization." @default.
• W3127375237 created "2021-02-15" @default.
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• W3127375237 date "2020-11-15" @default.
• W3127375237 modified "2023-10-17" @default.
• W3127375237 title "A Chemo-Mechanical Model of the Spreading of Endothelial Cells on the Lumen of Functionalized TEVGs" @default.
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• W3127375237 doi "https://doi.org/10.3390/iocn2020-07833" @default.
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