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• W3127394998 abstract "Olive and olive oil (OO) are a fundamental component of the Mediterranean culture and cuisine. Diverse traditional medicines include olive and its oil as a vital ingredient for the formulation of concoctions useful against urinary tract infection, diabetes, high blood pressure, hair loss, diarrhea, gout, rheumatism, mouth, and as a skin cleanser in various parts of the world. The use of OO as a healthy culinary ingredient has remained in vogue compared to other cooking oils given its promising benefits on the cardiovascular system among other health benefits. Indeed, results derived from in vitro, in vivo, and clinical studies have validated the potential benefits of olive and OO for the cardiovascular system. In vitro, both the methanolic and the ethanolic leaf extract downregulate hydroxynonenal-induced p-MAPKAPK-2 and p-c-Jun. Olive and OO are rich in bioactive metabolites such as oleuropein (OLE), hydroxytyrosol, and polyphenols. Notably, OLE inhibits the excess production of reactive oxygen species and stabilized mitochondrial membrane potential following simulated ischemia-/reperfusion-induced cardiomyocyte injury. In vivo, OLE reduced the plasma lipid peroxidation products and protein carbonyl levels in rabbits alongside providing strong antioxidant protection. Interestingly, it can also reduce doxorubicin-related cardiotoxicity. Both hydroxytyrosol and OLE significantly reversed chronic inflammation and oxidative stress consequently reducing cardiovascular, hepatic, and metabolic symptoms. Polyphenols also reduce chronic inflammation and oxidative stress. In furtherance, extra-virgin oil has demonstrated both cholesterol and blood pressure lowering properties while clinically decreasing cardiovascular disease risk by at least 35%. Virgin OO provides benefits among patients with stable coronary heart disease and can be employed as a supplement in patients with this disease." @default.
• W3127394998 created "2021-02-15" @default.
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• W3127394998 date "2021-01-01" @default.
• W3127394998 modified "2023-10-18" @default.
• W3127394998 title "Olive and olive oil: a one stop herbal solution for the prophylaxis and management of cardiovascular disorders" @default.
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• W3127394998 doi "https://doi.org/10.1016/b978-0-12-819528-4.00014-6" @default.
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