Matches in SemOpenAlex for { <https://semopenalex.org/work/W3127487629> ?p ?o ?g. }
- W3127487629 endingPage "1566" @default.
- W3127487629 startingPage "1566" @default.
- W3127487629 abstract "The effect of a cellular prion protein (PrPc) deficiency on neuroenergetics was primarily analyzed via surveying the expression of genes specifically involved in lactate/pyruvate metabolism, such as monocarboxylate transporters (MCT1, MCT2, MCT4). The aim of the present study was to elucidate a potential involvement of PrPc in the regulation of energy metabolism in different brain regions. By using quantitative real-time polymerase chain reaction (qRT-PCR), we observed a marked reduction in MCT1 mRNA expression in the cortex of symptomatic Zürich I Prnp−/− mice, as compared to their wild-type (WT) counterparts. MCT1 downregulation in the cortex was accompanied with significantly decreased expression of the MCT1 functional interplayer, the Na+/K+ ATPase α2 subunit. Conversely, the MCT1 mRNA level was significantly raised in the cerebellum of Prnp−/− vs. WT control group, without a substantial change in the Na+/K+ ATPase α2 subunit expression. To validate the observed mRNA findings, we confirmed the observed change in MCT1 mRNA expression level in the cortex at the protein level. MCT4, highly expressed in tissues that rely on glycolysis as an energy source, exhibited a significant reduction in the hippocampus of Prnp−/− vs. WT mice. The present study demonstrates that a lack of PrPc leads to altered MCT1 and MCT4 mRNA/protein expression in different brain regions of Prnp−/− vs. WT mice. Our findings provide evidence that PrPc might affect the monocarboxylate intercellular transport, which needs to be confirmed in further studies." @default.
- W3127487629 created "2021-02-15" @default.
- W3127487629 creator A5003282136 @default.
- W3127487629 creator A5005787374 @default.
- W3127487629 creator A5007540163 @default.
- W3127487629 creator A5023562049 @default.
- W3127487629 creator A5045897447 @default.
- W3127487629 date "2021-02-04" @default.
- W3127487629 modified "2023-10-12" @default.
- W3127487629 title "Altered mRNA and Protein Expression of Monocarboxylate Transporter MCT1 in the Cerebral Cortex and Cerebellum of Prion Protein Knockout Mice" @default.
- W3127487629 cites W1983466024 @default.
- W3127487629 cites W1992380356 @default.
- W3127487629 cites W2000999460 @default.
- W3127487629 cites W2001725826 @default.
- W3127487629 cites W2005681251 @default.
- W3127487629 cites W2011445998 @default.
- W3127487629 cites W2028338391 @default.
- W3127487629 cites W2030731207 @default.
- W3127487629 cites W2038811384 @default.
- W3127487629 cites W2039168977 @default.
- W3127487629 cites W2049475182 @default.
- W3127487629 cites W2050396172 @default.
- W3127487629 cites W2059585471 @default.
- W3127487629 cites W2061678350 @default.
- W3127487629 cites W2081327351 @default.
- W3127487629 cites W2089173873 @default.
- W3127487629 cites W2094929448 @default.
- W3127487629 cites W2108072126 @default.
- W3127487629 cites W2112356703 @default.
- W3127487629 cites W2113367943 @default.
- W3127487629 cites W2128811092 @default.
- W3127487629 cites W2148611607 @default.
- W3127487629 cites W2249758853 @default.
- W3127487629 cites W2297957816 @default.
- W3127487629 cites W2330455542 @default.
- W3127487629 cites W2345747767 @default.
- W3127487629 cites W2413075001 @default.
- W3127487629 cites W2439886693 @default.
- W3127487629 cites W2565274192 @default.
- W3127487629 cites W2577245527 @default.
- W3127487629 cites W2805660344 @default.
- W3127487629 cites W2808396314 @default.
- W3127487629 cites W2884818571 @default.
- W3127487629 cites W2905362030 @default.
- W3127487629 cites W2963472606 @default.
- W3127487629 cites W3046436874 @default.
- W3127487629 cites W367905852 @default.
- W3127487629 doi "https://doi.org/10.3390/ijms22041566" @default.
- W3127487629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7913939" @default.
- W3127487629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33557247" @default.
- W3127487629 hasPublicationYear "2021" @default.
- W3127487629 type Work @default.
- W3127487629 sameAs 3127487629 @default.
- W3127487629 citedByCount "1" @default.
- W3127487629 countsByYear W31274876292021 @default.
- W3127487629 crossrefType "journal-article" @default.
- W3127487629 hasAuthorship W3127487629A5003282136 @default.
- W3127487629 hasAuthorship W3127487629A5005787374 @default.
- W3127487629 hasAuthorship W3127487629A5007540163 @default.
- W3127487629 hasAuthorship W3127487629A5023562049 @default.
- W3127487629 hasAuthorship W3127487629A5045897447 @default.
- W3127487629 hasBestOaLocation W31274876291 @default.
- W3127487629 hasConcept C104317684 @default.
- W3127487629 hasConcept C105580179 @default.
- W3127487629 hasConcept C126322002 @default.
- W3127487629 hasConcept C127561419 @default.
- W3127487629 hasConcept C134018914 @default.
- W3127487629 hasConcept C135763542 @default.
- W3127487629 hasConcept C149011108 @default.
- W3127487629 hasConcept C153911025 @default.
- W3127487629 hasConcept C182704531 @default.
- W3127487629 hasConcept C185592680 @default.
- W3127487629 hasConcept C20251656 @default.
- W3127487629 hasConcept C2778147599 @default.
- W3127487629 hasConcept C2779652256 @default.
- W3127487629 hasConcept C2781217356 @default.
- W3127487629 hasConcept C55493867 @default.
- W3127487629 hasConcept C62231903 @default.
- W3127487629 hasConcept C71924100 @default.
- W3127487629 hasConcept C86803240 @default.
- W3127487629 hasConceptScore W3127487629C104317684 @default.
- W3127487629 hasConceptScore W3127487629C105580179 @default.
- W3127487629 hasConceptScore W3127487629C126322002 @default.
- W3127487629 hasConceptScore W3127487629C127561419 @default.
- W3127487629 hasConceptScore W3127487629C134018914 @default.
- W3127487629 hasConceptScore W3127487629C135763542 @default.
- W3127487629 hasConceptScore W3127487629C149011108 @default.
- W3127487629 hasConceptScore W3127487629C153911025 @default.
- W3127487629 hasConceptScore W3127487629C182704531 @default.
- W3127487629 hasConceptScore W3127487629C185592680 @default.
- W3127487629 hasConceptScore W3127487629C20251656 @default.
- W3127487629 hasConceptScore W3127487629C2778147599 @default.
- W3127487629 hasConceptScore W3127487629C2779652256 @default.
- W3127487629 hasConceptScore W3127487629C2781217356 @default.
- W3127487629 hasConceptScore W3127487629C55493867 @default.
- W3127487629 hasConceptScore W3127487629C62231903 @default.
- W3127487629 hasConceptScore W3127487629C71924100 @default.
- W3127487629 hasConceptScore W3127487629C86803240 @default.