Matches in SemOpenAlex for { <https://semopenalex.org/work/W3127620575> ?p ?o ?g. }
- W3127620575 endingPage "055020" @default.
- W3127620575 startingPage "055020" @default.
- W3127620575 abstract "There has been a recent revival of interest in the FLASH effect, after experiments have shown normal tissue sparing capabilities of ultra-high-dose-rate radiation with no compromise on tumour growth restraint. A model has been developed to investigate the relative importance of a number of fundamental parameters considered to be involved in the oxygen depletion paradigm of induced radioresistance. An example eight-dimensional parameter space demonstrates the conditions under which radiation may induce sufficient depletion of oxygen for a diffusion-limited hypoxic cellular response. Initial results support experimental evidence that FLASH sparing is only achieved for dose rates on the order of tens of Gy s-1or higher, for a sufficiently high dose, and only for tissue that is slightly hypoxic at the time of radiation. We show that the FLASH effect is the result of a number of biological, radiochemical and delivery parameters. Also, the threshold dose for a FLASH effect occurring would be more prominent when the parameterisation was optimised to produce the maximum effect. The model provides a framework for further FLASH-related investigation and experimental design. An understanding of the mechanistic interactions producing an optimised FLASH effect is essential for its translation into clinical practice." @default.
- W3127620575 created "2021-02-15" @default.
- W3127620575 creator A5025579028 @default.
- W3127620575 creator A5033175497 @default.
- W3127620575 creator A5034350645 @default.
- W3127620575 creator A5050287039 @default.
- W3127620575 creator A5053648656 @default.
- W3127620575 creator A5072603787 @default.
- W3127620575 creator A5073323606 @default.
- W3127620575 creator A5088753620 @default.
- W3127620575 date "2021-02-25" @default.
- W3127620575 modified "2023-10-01" @default.
- W3127620575 title "Determining the parameter space for effective oxygen depletion for FLASH radiation therapy" @default.
- W3127620575 cites W1963558489 @default.
- W3127620575 cites W1967514356 @default.
- W3127620575 cites W1970464799 @default.
- W3127620575 cites W1984996499 @default.
- W3127620575 cites W1988557543 @default.
- W3127620575 cites W2000223014 @default.
- W3127620575 cites W2010638294 @default.
- W3127620575 cites W2018722597 @default.
- W3127620575 cites W2020165283 @default.
- W3127620575 cites W2021546920 @default.
- W3127620575 cites W2023956032 @default.
- W3127620575 cites W2037340070 @default.
- W3127620575 cites W2038739812 @default.
- W3127620575 cites W2041903419 @default.
- W3127620575 cites W2046901824 @default.
- W3127620575 cites W2059633577 @default.
- W3127620575 cites W2065520133 @default.
- W3127620575 cites W2068642471 @default.
- W3127620575 cites W2072963762 @default.
- W3127620575 cites W2086356330 @default.
- W3127620575 cites W2090961231 @default.
- W3127620575 cites W2112646398 @default.
- W3127620575 cites W2130265723 @default.
- W3127620575 cites W2134132201 @default.
- W3127620575 cites W2174912594 @default.
- W3127620575 cites W2204695292 @default.
- W3127620575 cites W2215306508 @default.
- W3127620575 cites W2217441961 @default.
- W3127620575 cites W2249870244 @default.
- W3127620575 cites W2394916905 @default.
- W3127620575 cites W2615754762 @default.
- W3127620575 cites W2619354600 @default.
- W3127620575 cites W2762502468 @default.
- W3127620575 cites W2769131763 @default.
- W3127620575 cites W2805362264 @default.
- W3127620575 cites W2886467811 @default.
- W3127620575 cites W2936488270 @default.
- W3127620575 cites W2940040835 @default.
- W3127620575 cites W2942632899 @default.
- W3127620575 cites W2946753897 @default.
- W3127620575 cites W2946988433 @default.
- W3127620575 cites W2953511739 @default.
- W3127620575 cites W2958174590 @default.
- W3127620575 cites W2965842837 @default.
- W3127620575 cites W2998202461 @default.
- W3127620575 cites W3009918684 @default.
- W3127620575 cites W3015048867 @default.
- W3127620575 cites W3015573239 @default.
- W3127620575 cites W3027517951 @default.
- W3127620575 doi "https://doi.org/10.1088/1361-6560/abe2ea" @default.
- W3127620575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8208623" @default.
- W3127620575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33535191" @default.
- W3127620575 hasPublicationYear "2021" @default.
- W3127620575 type Work @default.
- W3127620575 sameAs 3127620575 @default.
- W3127620575 citedByCount "19" @default.
- W3127620575 countsByYear W31276205752021 @default.
- W3127620575 countsByYear W31276205752022 @default.
- W3127620575 countsByYear W31276205752023 @default.
- W3127620575 crossrefType "journal-article" @default.
- W3127620575 hasAuthorship W3127620575A5025579028 @default.
- W3127620575 hasAuthorship W3127620575A5033175497 @default.
- W3127620575 hasAuthorship W3127620575A5034350645 @default.
- W3127620575 hasAuthorship W3127620575A5050287039 @default.
- W3127620575 hasAuthorship W3127620575A5053648656 @default.
- W3127620575 hasAuthorship W3127620575A5072603787 @default.
- W3127620575 hasAuthorship W3127620575A5073323606 @default.
- W3127620575 hasAuthorship W3127620575A5088753620 @default.
- W3127620575 hasBestOaLocation W31276205751 @default.
- W3127620575 hasConcept C111337013 @default.
- W3127620575 hasConcept C120665830 @default.
- W3127620575 hasConcept C121332964 @default.
- W3127620575 hasConcept C125118446 @default.
- W3127620575 hasConcept C12554922 @default.
- W3127620575 hasConcept C126322002 @default.
- W3127620575 hasConcept C153385146 @default.
- W3127620575 hasConcept C163372243 @default.
- W3127620575 hasConcept C177322064 @default.
- W3127620575 hasConcept C178790620 @default.
- W3127620575 hasConcept C185544564 @default.
- W3127620575 hasConcept C185592680 @default.
- W3127620575 hasConcept C186060115 @default.
- W3127620575 hasConcept C192562407 @default.
- W3127620575 hasConcept C2777526259 @default.
- W3127620575 hasConcept C3017588741 @default.