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- W3127656563 endingPage "189" @default.
- W3127656563 startingPage "123" @default.
- W3127656563 abstract "Drug metabolism and pharmacokinetic (DMPK) studies of Taxaceae/Cephalotaxaceae natural products, their semisynthetic derivatives and analogs are indispensable in the optimization of lead compounds and clinical therapy. These studies can lead to development of new drug entities with improved absorption, distribution, metabolism, excretion, and toxicity (ADME/T) profiles. Natural and semisynthetic taxanes may cause and could be affected by drug–drug interaction (DDI). Hence ADME/T studies of various taxane-containing formulations are important; to date, these studies indicate that the role of cytochrome p450s and drug transporters is more prominent than phase II drug-metabolizing enzymes. Mechanisms of taxane DMPK mediated by nuclear receptors, microRNAs, and single-nucleotide polymorphisms are being revealed. Herein the latest knowledge on these topics as well as the gaps in knowledge of the DMPK issues of Taxaceae/Cephalotaxaceae compounds are summarized. DDIs significantly impact the pharmacokinetics/pharmacodynamics performance of taxanes and coadministered chemicals, which may inspire researchers to develop novel formula. While the ADME/T profiles of some taxanes are well defined, DMPK studies should be extended to more Taxaceae/Cephalotaxaceae compounds, species, and Taxaceae/Cephalotaxaceae-involved formulations, which would be streamlined by versatile omics platforms and computational analyses. Further biopharmaceutical investigations will be beneficial to the translation of bench findings to the clinical applications." @default.
- W3127656563 created "2021-02-15" @default.
- W3127656563 creator A5015250303 @default.
- W3127656563 date "2021-01-01" @default.
- W3127656563 modified "2023-09-27" @default.
- W3127656563 title "Drug metabolism and pharmacokinetic diversity of Taxus medicinal compounds" @default.
- W3127656563 cites W1112944074 @default.
- W3127656563 cites W1158333236 @default.
- W3127656563 cites W1234534496 @default.
- W3127656563 cites W1430703314 @default.
- W3127656563 cites W1441169201 @default.
- W3127656563 cites W1485898139 @default.
- W3127656563 cites W1539293547 @default.
- W3127656563 cites W1557508962 @default.
- W3127656563 cites W1565139562 @default.
- W3127656563 cites W1570757468 @default.
- W3127656563 cites W1570879046 @default.
- W3127656563 cites W1577194306 @default.
- W3127656563 cites W1578044134 @default.
- W3127656563 cites W1593960462 @default.
- W3127656563 cites W1608291762 @default.
- W3127656563 cites W1685675634 @default.
- W3127656563 cites W1700609558 @default.
- W3127656563 cites W1726763215 @default.
- W3127656563 cites W1728621917 @default.
- W3127656563 cites W1819714333 @default.
- W3127656563 cites W1824555890 @default.
- W3127656563 cites W1837847359 @default.
- W3127656563 cites W1847433263 @default.
- W3127656563 cites W1847822888 @default.
- W3127656563 cites W1898909764 @default.
- W3127656563 cites W1902243229 @default.
- W3127656563 cites W1910136316 @default.
- W3127656563 cites W1931695105 @default.
- W3127656563 cites W1935757694 @default.
- W3127656563 cites W1937535260 @default.
- W3127656563 cites W1938778011 @default.
- W3127656563 cites W1946475820 @default.
- W3127656563 cites W1948766162 @default.
- W3127656563 cites W1959549225 @default.
- W3127656563 cites W1963601943 @default.
- W3127656563 cites W1964149195 @default.
- W3127656563 cites W1965525939 @default.
- W3127656563 cites W1965785026 @default.
- W3127656563 cites W1966606134 @default.
- W3127656563 cites W1969583688 @default.
- W3127656563 cites W1970057472 @default.
- W3127656563 cites W1970657168 @default.
- W3127656563 cites W1970688162 @default.
- W3127656563 cites W1971459895 @default.
- W3127656563 cites W1971797888 @default.
- W3127656563 cites W1972879639 @default.
- W3127656563 cites W1973335393 @default.
- W3127656563 cites W1974953002 @default.
- W3127656563 cites W1975433400 @default.
- W3127656563 cites W1977173693 @default.
- W3127656563 cites W1978962998 @default.
- W3127656563 cites W1979214808 @default.
- W3127656563 cites W1980130017 @default.
- W3127656563 cites W1981409936 @default.
- W3127656563 cites W1981737320 @default.
- W3127656563 cites W1982052805 @default.
- W3127656563 cites W1986216802 @default.
- W3127656563 cites W1987083822 @default.
- W3127656563 cites W1987541669 @default.
- W3127656563 cites W1991590537 @default.
- W3127656563 cites W1991679686 @default.
- W3127656563 cites W1992722589 @default.
- W3127656563 cites W1992941142 @default.
- W3127656563 cites W1993440026 @default.
- W3127656563 cites W1994004247 @default.
- W3127656563 cites W1994572190 @default.
- W3127656563 cites W1995811281 @default.
- W3127656563 cites W1997452217 @default.
- W3127656563 cites W1997789582 @default.
- W3127656563 cites W1998458742 @default.
- W3127656563 cites W1998541081 @default.
- W3127656563 cites W2002522862 @default.
- W3127656563 cites W2002632145 @default.
- W3127656563 cites W2009461889 @default.
- W3127656563 cites W2009596413 @default.
- W3127656563 cites W2012290878 @default.
- W3127656563 cites W2013143656 @default.
- W3127656563 cites W2016849687 @default.
- W3127656563 cites W2017577682 @default.
- W3127656563 cites W2018646812 @default.
- W3127656563 cites W2019491653 @default.
- W3127656563 cites W2020302755 @default.
- W3127656563 cites W2021250530 @default.
- W3127656563 cites W2022465511 @default.
- W3127656563 cites W2024674972 @default.
- W3127656563 cites W2024934506 @default.
- W3127656563 cites W2028694954 @default.
- W3127656563 cites W2028998396 @default.
- W3127656563 cites W2029849864 @default.
- W3127656563 cites W2030607193 @default.
- W3127656563 cites W2031291107 @default.
- W3127656563 cites W2032559241 @default.