Matches in SemOpenAlex for { <https://semopenalex.org/work/W3127675558> ?p ?o ?g. }
- W3127675558 endingPage "1064" @default.
- W3127675558 startingPage "1056" @default.
- W3127675558 abstract "Glioblastoma multiforme (GBM) are the most common and among the deadliest brain tumors in adults. Current mainstay treatments are insufficient to treat this tumor, and therefore, more effective therapies are desperately needed. Immunotherapy, which takes advantage of the body's natural defense mechanism, is an exciting emerging field in neuro-oncology. Adoptive cell therapy with chimeric antigen receptor (CAR) T cells provides a treatment strategy based on using patients' own selected and genetically engineered cells that target tumor-associated antigens. These cells are harvested from patients, modified to target specific proteins expressed by the tumor, and re-introduced into the patient with the goal of destroying tumor cells. Here, we review the history of CAR T-cell therapy, and describe the characteristics of various generations of CAR T therapies, and the challenges inherent to treatment of GBM. Finally, we describe recent and current CAR T clinical trials designed to combat GBM." @default.
- W3127675558 created "2021-02-15" @default.
- W3127675558 creator A5010868067 @default.
- W3127675558 creator A5020359747 @default.
- W3127675558 creator A5080598896 @default.
- W3127675558 date "2021-02-11" @default.
- W3127675558 modified "2023-10-17" @default.
- W3127675558 title "Chimeric Antigen Receptor T-Cell Therapy: Updates in Glioblastoma Treatment" @default.
- W3127675558 cites W1254161066 @default.
- W3127675558 cites W1624657716 @default.
- W3127675558 cites W1828443506 @default.
- W3127675558 cites W1877911682 @default.
- W3127675558 cites W1885893763 @default.
- W3127675558 cites W1929145004 @default.
- W3127675558 cites W1969731848 @default.
- W3127675558 cites W1997424206 @default.
- W3127675558 cites W2006285921 @default.
- W3127675558 cites W2007753376 @default.
- W3127675558 cites W2030718440 @default.
- W3127675558 cites W2038702089 @default.
- W3127675558 cites W2042765435 @default.
- W3127675558 cites W2046562334 @default.
- W3127675558 cites W2047205338 @default.
- W3127675558 cites W2063407855 @default.
- W3127675558 cites W2064272625 @default.
- W3127675558 cites W2070748533 @default.
- W3127675558 cites W2072798909 @default.
- W3127675558 cites W2077476931 @default.
- W3127675558 cites W2079577433 @default.
- W3127675558 cites W2082708772 @default.
- W3127675558 cites W2084461677 @default.
- W3127675558 cites W2087857484 @default.
- W3127675558 cites W2092692114 @default.
- W3127675558 cites W2094945699 @default.
- W3127675558 cites W2106161829 @default.
- W3127675558 cites W2109839172 @default.
- W3127675558 cites W2111034570 @default.
- W3127675558 cites W2115240522 @default.
- W3127675558 cites W2118373577 @default.
- W3127675558 cites W2121170253 @default.
- W3127675558 cites W2125493895 @default.
- W3127675558 cites W2129387595 @default.
- W3127675558 cites W2135465849 @default.
- W3127675558 cites W2136100686 @default.
- W3127675558 cites W2137605317 @default.
- W3127675558 cites W2152165755 @default.
- W3127675558 cites W2159222883 @default.
- W3127675558 cites W2161289668 @default.
- W3127675558 cites W2163695893 @default.
- W3127675558 cites W2169579205 @default.
- W3127675558 cites W2181071874 @default.
- W3127675558 cites W2253972308 @default.
- W3127675558 cites W2260497117 @default.
- W3127675558 cites W2334343715 @default.
- W3127675558 cites W2396185671 @default.
- W3127675558 cites W2398722604 @default.
- W3127675558 cites W2419671718 @default.
- W3127675558 cites W2475107749 @default.
- W3127675558 cites W2518901881 @default.
- W3127675558 cites W2560005855 @default.
- W3127675558 cites W2566018578 @default.
- W3127675558 cites W2567424265 @default.
- W3127675558 cites W2605626471 @default.
- W3127675558 cites W2738678436 @default.
- W3127675558 cites W2746068181 @default.
- W3127675558 cites W2755677601 @default.
- W3127675558 cites W2763751953 @default.
- W3127675558 cites W2768442299 @default.
- W3127675558 cites W2773804840 @default.
- W3127675558 cites W2787301955 @default.
- W3127675558 cites W2787621143 @default.
- W3127675558 cites W2790865199 @default.
- W3127675558 cites W2793992337 @default.
- W3127675558 cites W2796073384 @default.
- W3127675558 cites W2805523469 @default.
- W3127675558 cites W2901390118 @default.
- W3127675558 cites W2922661875 @default.
- W3127675558 cites W2947882832 @default.
- W3127675558 cites W2961217357 @default.
- W3127675558 cites W2963298310 @default.
- W3127675558 cites W3009044390 @default.
- W3127675558 cites W47013412 @default.
- W3127675558 doi "https://doi.org/10.1093/neuros/nyaa584" @default.
- W3127675558 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8324243" @default.
- W3127675558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33575786" @default.
- W3127675558 hasPublicationYear "2021" @default.
- W3127675558 type Work @default.
- W3127675558 sameAs 3127675558 @default.
- W3127675558 citedByCount "13" @default.
- W3127675558 countsByYear W31276755582021 @default.
- W3127675558 countsByYear W31276755582022 @default.
- W3127675558 countsByYear W31276755582023 @default.
- W3127675558 crossrefType "journal-article" @default.
- W3127675558 hasAuthorship W3127675558A5010868067 @default.
- W3127675558 hasAuthorship W3127675558A5020359747 @default.
- W3127675558 hasAuthorship W3127675558A5080598896 @default.
- W3127675558 hasBestOaLocation W31276755582 @default.
- W3127675558 hasConcept C104317684 @default.