Matches in SemOpenAlex for { <https://semopenalex.org/work/W3127705515> ?p ?o ?g. }
- W3127705515 abstract "Allergic diseases are pathological immune responses with significant morbidity, which are closely associated with allergic mediators as released by allergen-stimulated mast cells (MCs). Prophylactic stabilization of MCs is regarded as a practical approach to prevent allergic diseases. However, most of the existing small molecular MC stabilizers exhibit a narrow therapeutic time window, failing to provide long-term prevention of allergic diseases. Herein, ceria nanoparticle (CeNP-) based phosphatase-mimetic nano-stabilizers (PMNSs) with a long-term therapeutic time window are developed for allergic disease prevention. By virtue of the regenerable catalytic hotspots of oxygen vacancies on the surface of CeNPs, PMNSs exhibit sustainable phosphatase-mimetic activity to dephosphorylate phosphoproteins in allergen-stimulated MCs. Consequently, PMNSs constantly modulate intracellular phospho-signaling cascades of MCs to inhibit the degranulation of allergic mediators, which prevents the initiation of allergic mediator-associated pathological responses, eventually providing protection against allergic diseases with a long-term therapeutic time window." @default.
- W3127705515 created "2021-02-15" @default.
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- W3127705515 date "2021-02-08" @default.
- W3127705515 modified "2023-10-17" @default.
- W3127705515 title "A Phosphatase‐Mimetic Nano‐Stabilizer of Mast Cells for Long‐Term Prevention of Allergic Disease" @default.
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- W3127705515 doi "https://doi.org/10.1002/advs.202004115" @default.
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