Matches in SemOpenAlex for { <https://semopenalex.org/work/W3127707267> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W3127707267 endingPage "AB65" @default.
- W3127707267 startingPage "AB65" @default.
- W3127707267 abstract "Common Variable Immunodeficiency (CVID) is defined by low serum immunoglobulins, history of recurrent sinopulmonary infections, and blunted response to immunization. It can be associated with immune dysregulation. Though not well documented, it has been clinically suspected that CVID may be associated with allergic disease. We set out to determine a possible connection. This retrospective study was conducted at the George Washington University. Study patients were identified with ICD-10 diagnoses of primary immunodeficiencies in an electronic medical record (EMR). Of 541 patients with one or more such diagnoses, 88 patients had a confirmed diagnosis of CVID. Of the 88 patients, 43 (48.9%) patients were diagnosed with allergic rhinitis by an Allergist with 7 (78%) out of 9 patients reporting improvement in symptoms with allergen immunotherapy. 22 of the 88 patients underwent skin testing of which 20 (91%) were found to be positive. Of the 88 patients, 46 (52.3%) patients were receiving IVIG replacement therapy. 21 (45.7%) of these 46 patients were asked if IVIG helped their allergic symptoms of which 18 (85.7%) of the 21 patients reported improvement. Interestingly, the mean Immunoglobulin E (IgE) was found to be 67.5 and mean eosinophils were 200. The high incidence of allergic disease, positive skin testing, and elevated IgE and eosinophils in these patients suggests a potential interaction between Th1 and Th2 immunity that might explain why patients with CVID have allergic disease. An improvement in allergic symptoms in CVID patients on IVIG further points to a possible connection between allergic disease and CVID." @default.
- W3127707267 created "2021-02-15" @default.
- W3127707267 creator A5002280593 @default.
- W3127707267 creator A5020457225 @default.
- W3127707267 creator A5024439067 @default.
- W3127707267 creator A5024529761 @default.
- W3127707267 creator A5042278898 @default.
- W3127707267 creator A5048030932 @default.
- W3127707267 creator A5087786133 @default.
- W3127707267 creator A5090041490 @default.
- W3127707267 date "2021-02-01" @default.
- W3127707267 modified "2023-10-06" @default.
- W3127707267 title "Overlay Between Th1 and Th2 pathways in Patients with Common Variable Immunodeficiency and Allergic disease" @default.
- W3127707267 doi "https://doi.org/10.1016/j.jaci.2020.12.256" @default.
- W3127707267 hasPublicationYear "2021" @default.
- W3127707267 type Work @default.
- W3127707267 sameAs 3127707267 @default.
- W3127707267 citedByCount "0" @default.
- W3127707267 crossrefType "journal-article" @default.
- W3127707267 hasAuthorship W3127707267A5002280593 @default.
- W3127707267 hasAuthorship W3127707267A5020457225 @default.
- W3127707267 hasAuthorship W3127707267A5024439067 @default.
- W3127707267 hasAuthorship W3127707267A5024529761 @default.
- W3127707267 hasAuthorship W3127707267A5042278898 @default.
- W3127707267 hasAuthorship W3127707267A5048030932 @default.
- W3127707267 hasAuthorship W3127707267A5087786133 @default.
- W3127707267 hasAuthorship W3127707267A5090041490 @default.
- W3127707267 hasBestOaLocation W31277072671 @default.
- W3127707267 hasConcept C120665830 @default.
- W3127707267 hasConcept C121332964 @default.
- W3127707267 hasConcept C126322002 @default.
- W3127707267 hasConcept C141105273 @default.
- W3127707267 hasConcept C159654299 @default.
- W3127707267 hasConcept C203014093 @default.
- W3127707267 hasConcept C207480886 @default.
- W3127707267 hasConcept C2776433325 @default.
- W3127707267 hasConcept C2777607303 @default.
- W3127707267 hasConcept C2779019163 @default.
- W3127707267 hasConcept C2779134260 @default.
- W3127707267 hasConcept C61511704 @default.
- W3127707267 hasConcept C71924100 @default.
- W3127707267 hasConcept C8891405 @default.
- W3127707267 hasConceptScore W3127707267C120665830 @default.
- W3127707267 hasConceptScore W3127707267C121332964 @default.
- W3127707267 hasConceptScore W3127707267C126322002 @default.
- W3127707267 hasConceptScore W3127707267C141105273 @default.
- W3127707267 hasConceptScore W3127707267C159654299 @default.
- W3127707267 hasConceptScore W3127707267C203014093 @default.
- W3127707267 hasConceptScore W3127707267C207480886 @default.
- W3127707267 hasConceptScore W3127707267C2776433325 @default.
- W3127707267 hasConceptScore W3127707267C2777607303 @default.
- W3127707267 hasConceptScore W3127707267C2779019163 @default.
- W3127707267 hasConceptScore W3127707267C2779134260 @default.
- W3127707267 hasConceptScore W3127707267C61511704 @default.
- W3127707267 hasConceptScore W3127707267C71924100 @default.
- W3127707267 hasConceptScore W3127707267C8891405 @default.
- W3127707267 hasIssue "2" @default.
- W3127707267 hasLocation W31277072671 @default.
- W3127707267 hasOpenAccess W3127707267 @default.
- W3127707267 hasPrimaryLocation W31277072671 @default.
- W3127707267 hasRelatedWork W1859477696 @default.
- W3127707267 hasRelatedWork W1915809870 @default.
- W3127707267 hasRelatedWork W2014482706 @default.
- W3127707267 hasRelatedWork W2084801194 @default.
- W3127707267 hasRelatedWork W2088137261 @default.
- W3127707267 hasRelatedWork W2188477198 @default.
- W3127707267 hasRelatedWork W2399328311 @default.
- W3127707267 hasRelatedWork W2412876563 @default.
- W3127707267 hasRelatedWork W2414918210 @default.
- W3127707267 hasRelatedWork W2803613523 @default.
- W3127707267 hasVolume "147" @default.
- W3127707267 isParatext "false" @default.
- W3127707267 isRetracted "false" @default.
- W3127707267 magId "3127707267" @default.
- W3127707267 workType "article" @default.