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• W3127748314 abstract "Neuroinflammation driven by type-I interferons in the CNS is well established to exacerbate the progression of many CNS pathologies both acute and chronic. The role of adaptor protein Stimulator of Interferon Genes (STING) is increasingly appreciated to instigate type-I IFN-mediated neuroinflammation. As an upstream regulator of type-I IFNs, STING modulation presents a novel therapeutic opportunity to mediate inflammation in the CNS. This review will detail the current knowledge of protective and detrimental STING activity in acute and chronic CNS pathologies and the current therapeutic avenues being explored." @default.
• W3127748314 created "2021-02-15" @default.
• W3127748314 creator A5036677298 @default.
• W3127748314 creator A5039539160 @default.
• W3127748314 creator A5049490992 @default.
• W3127748314 creator A5064944464 @default.
• W3127748314 date "2021-02-09" @default.
• W3127748314 modified "2023-09-30" @default.
• W3127748314 title "The Complexity of the cGAS-STING Pathway in CNS Pathologies" @default.
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