Matches in SemOpenAlex for { <https://semopenalex.org/work/W3127758985> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3127758985 abstract "Carbon tetrachloride (CCl4) is a dynamic environmental toxin released from chemical factories and its concentration in the atmosphere is accelerating at an alarming proportion. The potential presence of CCl4 in the human body causes liver injury via free radical stimulated inflammatory responses.In this study, protective effects of hydromethanolic seeds extract of Prunus persica (PPHM) were evaluated for free radical scavenging potential in CCl4 mediated acute liver toxicity in the murine model.Followed by acute oral toxicity analysis, liver cells of Sprague-Dawley (SD) rats were treated with CCl4 and subsequently, the chemoprophylactic effect of extract (400 mg/Kg dose) was evaluated using in vivo studies including, silymarin as the positive control. Biochemical parameters, staining (hematoxylin and eosin (H & E) and Masson's Trichome) and quantitative gene expression analysis via real-time PCR were used to evaluate hepatic damage control.The results illustrated that PPHM extract exhibit strong anti-oxidant activity, comparable to the positive control, gallic acid. Research study results also demonstrated that the extract treatment at 400 mg/Kg concentration is highly effective in protecting liver damage due to CCl4 exposure. Mechanistic investigations indicated that the therapeutic action of PPHM was correlated with the increase in Nrf2, NQO-1 and decrease in collagen III mRNA genes expression compared to CCl4 treated group.Accordingly, our research study indicated that PPHM alleviated CCl4-mediated oxidative stress through Nrf2/NQO-1 pathway, thereby protecting liver damage against environmental toxins. Our findings provide supportive evidence to suggest PPHM as a novel nontoxic hepatoprotective agent." @default.
- W3127758985 created "2021-02-15" @default.
- W3127758985 creator A5002947699 @default.
- W3127758985 creator A5005000729 @default.
- W3127758985 creator A5014023164 @default.
- W3127758985 creator A5015188618 @default.
- W3127758985 creator A5027815597 @default.
- W3127758985 creator A5045920908 @default.
- W3127758985 creator A5052459302 @default.
- W3127758985 creator A5056370990 @default.
- W3127758985 creator A5070974938 @default.
- W3127758985 date "2021-02-03" @default.
- W3127758985 modified "2023-09-26" @default.
- W3127758985 title "Phytochemical Screening and Protective Effects of Prunus persica Seeds Extract on Carbon Tetrachloride-Induced Hepatic Injury in Rats" @default.
- W3127758985 doi "https://doi.org/10.2174/1389201022666210203142138" @default.
- W3127758985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33535946" @default.
- W3127758985 hasPublicationYear "2021" @default.
- W3127758985 type Work @default.
- W3127758985 sameAs 3127758985 @default.
- W3127758985 citedByCount "1" @default.
- W3127758985 countsByYear W31277589852021 @default.
- W3127758985 crossrefType "journal-article" @default.
- W3127758985 hasAuthorship W3127758985A5002947699 @default.
- W3127758985 hasAuthorship W3127758985A5005000729 @default.
- W3127758985 hasAuthorship W3127758985A5014023164 @default.
- W3127758985 hasAuthorship W3127758985A5015188618 @default.
- W3127758985 hasAuthorship W3127758985A5027815597 @default.
- W3127758985 hasAuthorship W3127758985A5045920908 @default.
- W3127758985 hasAuthorship W3127758985A5052459302 @default.
- W3127758985 hasAuthorship W3127758985A5056370990 @default.
- W3127758985 hasAuthorship W3127758985A5070974938 @default.
- W3127758985 hasConcept C102124568 @default.
- W3127758985 hasConcept C150903083 @default.
- W3127758985 hasConcept C178790620 @default.
- W3127758985 hasConcept C185592680 @default.
- W3127758985 hasConcept C195475562 @default.
- W3127758985 hasConcept C207001950 @default.
- W3127758985 hasConcept C2776151105 @default.
- W3127758985 hasConcept C2776637226 @default.
- W3127758985 hasConcept C2777359374 @default.
- W3127758985 hasConcept C2778004101 @default.
- W3127758985 hasConcept C2778362808 @default.
- W3127758985 hasConcept C29730261 @default.
- W3127758985 hasConcept C55493867 @default.
- W3127758985 hasConcept C86803240 @default.
- W3127758985 hasConcept C98274493 @default.
- W3127758985 hasConceptScore W3127758985C102124568 @default.
- W3127758985 hasConceptScore W3127758985C150903083 @default.
- W3127758985 hasConceptScore W3127758985C178790620 @default.
- W3127758985 hasConceptScore W3127758985C185592680 @default.
- W3127758985 hasConceptScore W3127758985C195475562 @default.
- W3127758985 hasConceptScore W3127758985C207001950 @default.
- W3127758985 hasConceptScore W3127758985C2776151105 @default.
- W3127758985 hasConceptScore W3127758985C2776637226 @default.
- W3127758985 hasConceptScore W3127758985C2777359374 @default.
- W3127758985 hasConceptScore W3127758985C2778004101 @default.
- W3127758985 hasConceptScore W3127758985C2778362808 @default.
- W3127758985 hasConceptScore W3127758985C29730261 @default.
- W3127758985 hasConceptScore W3127758985C55493867 @default.
- W3127758985 hasConceptScore W3127758985C86803240 @default.
- W3127758985 hasConceptScore W3127758985C98274493 @default.
- W3127758985 hasLocation W31277589851 @default.
- W3127758985 hasLocation W31277589852 @default.
- W3127758985 hasOpenAccess W3127758985 @default.
- W3127758985 hasPrimaryLocation W31277589851 @default.
- W3127758985 hasRelatedWork W1822321968 @default.
- W3127758985 hasRelatedWork W2009561570 @default.
- W3127758985 hasRelatedWork W2029400286 @default.
- W3127758985 hasRelatedWork W2257222697 @default.
- W3127758985 hasRelatedWork W2418306441 @default.
- W3127758985 hasRelatedWork W3006814219 @default.
- W3127758985 hasRelatedWork W3207011387 @default.
- W3127758985 hasRelatedWork W4281801589 @default.
- W3127758985 hasRelatedWork W2460980786 @default.
- W3127758985 hasRelatedWork W2640481288 @default.
- W3127758985 hasVolume "22" @default.
- W3127758985 isParatext "false" @default.
- W3127758985 isRetracted "false" @default.
- W3127758985 magId "3127758985" @default.
- W3127758985 workType "article" @default.