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- W3127830457 abstract "Mannosylerythritol lipids (MELs) are surface active glycolipids secreted by various fungi. MELs can be used as biosurfactants and are a biodegradable resource for the production of detergents or pharmaceuticals. Different fungal species synthesize a unique mixture of MELs differing in acetyl- and acyl-groups attached to the sugar moiety. Here, we report the construction of a toolbox for production of glycolipids with predictable fatty acid side chains in the basidiomycete Ustilago maydis. Genes coding for acyl-transferases involved in MEL production (Mac1 and Mac2) from different fungal species were combined to obtain altered MEL variants with distinct physical properties and altered antimicrobial activity. We also demonstrate that a U. maydis paralog of the acyltransferase Mac2 with a different substrate specificity can be employed for the biosynthesis of modified MEL variants. In summary, our data showcase how the fungal repertoire of Mac enzymes can be used to engineer tailor-made MELs according to specific biotechnological or pharmaceutical requirements." @default.
- W3127830457 created "2021-02-15" @default.
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- W3127830457 date "2021-06-01" @default.
- W3127830457 modified "2023-09-25" @default.
- W3127830457 title "Engineering Ustilago maydis for production of tailor-made mannosylerythritol lipids" @default.
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- W3127830457 doi "https://doi.org/10.1016/j.mec.2021.e00165" @default.
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