Matches in SemOpenAlex for { <https://semopenalex.org/work/W3127916753> ?p ?o ?g. }
- W3127916753 abstract "Early-stage diagnosis of pancreatic ductal adenocarcinoma (PDAC) is difficult due to non-specific symptoms. Circulating miRNAs in body fluids have been emerging as potential non-invasive biomarkers for diagnosis of many cancers. Thus, this study aimed to assess a panel of miRNAs for their ability to differentiate PDAC from chronic pancreatitis (CP), a benign inflammatory condition of the pancreas. Next-generation sequencing was performed to identify miRNAs present in 60 FFPE tissue samples (27 PDAC, 23 CP and 10 normal pancreatic tissues). Four up-regulated miRNAs (miR-215-5p, miR-122-5p, miR-192-5p, and miR-181a-2-3p) and four down-regulated miRNAs (miR-30b-5p, miR-216b-5p, miR-320b, and miR-214-5p) in PDAC compared to CP were selected based on next-generation sequencing results. The levels of these 8 differentially expressed miRNAs were measured by qRT-PCR in 125 serum samples (50 PDAC, 50 CP, and 25 healthy controls (HC)). The results showed significant upregulation of miR-215-5p, miR-122-5p, and miR-192-5p in PDAC serum samples. In contrast, levels of miR-30b-5p and miR-320b were significantly lower in PDAC as compared to CP and HC. ROC analysis showed that these 5 miRNAs can distinguish PDAC from both CP and HC. Hence, this panel can serve as a non-invasive biomarker for the early detection of PDAC." @default.
- W3127916753 created "2021-02-15" @default.
- W3127916753 creator A5000292665 @default.
- W3127916753 creator A5006233870 @default.
- W3127916753 creator A5009952069 @default.
- W3127916753 creator A5015279222 @default.
- W3127916753 creator A5024463062 @default.
- W3127916753 creator A5038826897 @default.
- W3127916753 creator A5043119200 @default.
- W3127916753 creator A5058935905 @default.
- W3127916753 creator A5062119044 @default.
- W3127916753 creator A5064412940 @default.
- W3127916753 creator A5071724177 @default.
- W3127916753 date "2021-02-02" @default.
- W3127916753 modified "2023-10-03" @default.
- W3127916753 title "Panel of serum miRNAs as potential non-invasive biomarkers for pancreatic ductal adenocarcinoma" @default.
- W3127916753 cites W144423133 @default.
- W3127916753 cites W1976284083 @default.
- W3127916753 cites W1981337389 @default.
- W3127916753 cites W1986110037 @default.
- W3127916753 cites W1992303379 @default.
- W3127916753 cites W2019867275 @default.
- W3127916753 cites W2020080445 @default.
- W3127916753 cites W2026595595 @default.
- W3127916753 cites W2039431935 @default.
- W3127916753 cites W2051227958 @default.
- W3127916753 cites W2055585366 @default.
- W3127916753 cites W2071742896 @default.
- W3127916753 cites W2075060873 @default.
- W3127916753 cites W2079251691 @default.
- W3127916753 cites W2097233439 @default.
- W3127916753 cites W2109227959 @default.
- W3127916753 cites W2115093090 @default.
- W3127916753 cites W2118257856 @default.
- W3127916753 cites W2130979840 @default.
- W3127916753 cites W2139992910 @default.
- W3127916753 cites W2141531961 @default.
- W3127916753 cites W2161957137 @default.
- W3127916753 cites W2334205428 @default.
- W3127916753 cites W2395712365 @default.
- W3127916753 cites W2408666766 @default.
- W3127916753 cites W2414385880 @default.
- W3127916753 cites W2468822411 @default.
- W3127916753 cites W2488974482 @default.
- W3127916753 cites W2549598713 @default.
- W3127916753 cites W2565628110 @default.
- W3127916753 cites W2565838736 @default.
- W3127916753 cites W2590620977 @default.
- W3127916753 cites W2591797433 @default.
- W3127916753 cites W2598674107 @default.
- W3127916753 cites W2615072496 @default.
- W3127916753 cites W2615757532 @default.
- W3127916753 cites W2733309113 @default.
- W3127916753 cites W2736520162 @default.
- W3127916753 cites W2782898644 @default.
- W3127916753 cites W2805282558 @default.
- W3127916753 cites W2808012852 @default.
- W3127916753 cites W2809253370 @default.
- W3127916753 cites W2810666617 @default.
- W3127916753 cites W2893410282 @default.
- W3127916753 cites W2901783992 @default.
- W3127916753 cites W2911188335 @default.
- W3127916753 cites W2940522838 @default.
- W3127916753 cites W2941516353 @default.
- W3127916753 cites W2944010518 @default.
- W3127916753 cites W2957293676 @default.
- W3127916753 cites W2964711166 @default.
- W3127916753 cites W2983778661 @default.
- W3127916753 cites W2992997309 @default.
- W3127916753 cites W3003686046 @default.
- W3127916753 cites W3013167825 @default.
- W3127916753 cites W3014945596 @default.
- W3127916753 cites W3017035671 @default.
- W3127916753 cites W3026644954 @default.
- W3127916753 cites W3037590290 @default.
- W3127916753 cites W3045659347 @default.
- W3127916753 cites W3047278566 @default.
- W3127916753 cites W3049413897 @default.
- W3127916753 doi "https://doi.org/10.1038/s41598-021-82266-5" @default.
- W3127916753 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7854650" @default.
- W3127916753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33531550" @default.
- W3127916753 hasPublicationYear "2021" @default.
- W3127916753 type Work @default.
- W3127916753 sameAs 3127916753 @default.
- W3127916753 citedByCount "25" @default.
- W3127916753 countsByYear W31279167532021 @default.
- W3127916753 countsByYear W31279167532022 @default.
- W3127916753 countsByYear W31279167532023 @default.
- W3127916753 crossrefType "journal-article" @default.
- W3127916753 hasAuthorship W3127916753A5000292665 @default.
- W3127916753 hasAuthorship W3127916753A5006233870 @default.
- W3127916753 hasAuthorship W3127916753A5009952069 @default.
- W3127916753 hasAuthorship W3127916753A5015279222 @default.
- W3127916753 hasAuthorship W3127916753A5024463062 @default.
- W3127916753 hasAuthorship W3127916753A5038826897 @default.
- W3127916753 hasAuthorship W3127916753A5043119200 @default.
- W3127916753 hasAuthorship W3127916753A5058935905 @default.
- W3127916753 hasAuthorship W3127916753A5062119044 @default.
- W3127916753 hasAuthorship W3127916753A5064412940 @default.
- W3127916753 hasAuthorship W3127916753A5071724177 @default.