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• W3127921963 endingPage "100913" @default.
• W3127921963 startingPage "100913" @default.
• W3127921963 abstract "Serum albumin (SA) acts as the carrier protein to transport drugs and plays a crucial role in the pharmacokinetics of distribution. In this work, the cytotoxicities of 20(S, R)-protopanaxadiol [20(S, R)-PPD] and 20(S, R)-protopanaxatriol [20(S, R)-PPT] against HCT-116 cell lines were assessed. 20(S)-PPD, 20(R)-PPD, 20(S)-PPT, and 20(R)-PPT inhibited the cells growth in a concentration-dependent manner with the IC50 values of 30.27, 18.80, 68.28, and 14.38 μM, respectively. The result of ABTS assay showed that 20(S, R)-PPD-BSA exhibited a higher antioxidant activity than that of 20(S, R)-PPD alone. Subsequently, the binding affinity and interaction mechanism of ginsenosides with SA were studied by the ultraviolet–visible absorption and fluorescence spectroscopy, which indicated that ginsenosides interfered with the microenvironment around amide bonds in SA. Through the calculation of Stern-Volmer plot, the quenching rate kq values of 20(S)-PPD, 20(R)-PPD, 20(S)-PPT, and 20(R)-PPT were 6.75, 4.30, 2.37, and 3.31 ( × 1011 M−1 s−1), respectively. These results suggested that the quenching was not caused by dynamic collision, but the formation of ginsenoside-SA complexes. The results of molecular docking suggested that these compounds tended to bind more strongly to Sudlow's site II of HSA rather than Sudlow's site I. In addition, 20(S)-ginsenosides showed more stable binding to HSA in comparison with 20(R)-ginsenosides, which may help elucidating the mechanisms that account for the stronger bioactivities of 20(S)-ginsenosides." @default.
• W3127921963 created "2021-02-15" @default.
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• W3127921963 date "2021-04-01" @default.
• W3127921963 modified "2023-09-25" @default.
• W3127921963 title "Multi-spectroscopic and molecular modeling studies on the interactions of serum albumin with 20(S, R)-protopanaxadiol and 20(S, R)-protopanaxatriol that inhibit HCT-116 cells proliferation" @default.
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• W3127921963 doi "https://doi.org/10.1016/j.fbio.2021.100913" @default.
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