Matches in SemOpenAlex for { <https://semopenalex.org/work/W3127935100> ?p ?o ?g. }
- W3127935100 abstract "Abstract Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are two distinct autoimmune diseases that manifest with chronic synovial inflammation. Here, we show that CD4 + T cells from patients with RA and PsA have increased expression of the pore-forming calcium channel component ORAI3, thereby increasing the activity of the arachidonic acid-regulated calcium-selective (ARC) channel and making T cells sensitive to arachidonic acid. A similar increase does not occur in T cells from patients with systemic lupus erythematosus. Increased ORAI3 transcription in RA and PsA T cells is caused by reduced IKAROS expression, a transcriptional repressor of the ORAI3 promoter. Stimulation of the ARC channel with arachidonic acid induces not only a calcium influx, but also the phosphorylation of components of the T cell receptor signaling cascade. In a human synovium chimeric mouse model, silencing ORAI3 expression in adoptively transferred T cells from patients with RA attenuates tissue inflammation, while adoptive transfer of T cells from healthy individuals with reduced expression of IKAROS induces synovitis. We propose that increased ARC activity due to reduced IKAROS expression makes T cells more responsive and contributes to chronic inflammation in RA and PsA." @default.
- W3127935100 created "2021-02-15" @default.
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- W3127935100 date "2021-02-10" @default.
- W3127935100 modified "2023-10-18" @default.
- W3127935100 title "Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation" @default.
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- W3127935100 doi "https://doi.org/10.1038/s41467-021-21242-z" @default.
- W3127935100 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7875984" @default.
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