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- W3127966108 endingPage "137" @default.
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- W3127966108 abstract "Monoclonal antibodies (mAbs) are now considered as a therapeutic approach to prevent and treat severe viral infections. Using a mouse retroviral model, we showed that mAbs induce protective immunity (vaccinal effects). Here, we investigated the role of natural killer (NK) cells on this effect. NK cells are effector cells that are crucial to control viral propagation upon mAb treatment. However, their immunomodulatory activity during antiviral mAb immunotherapies has been little studied. Our data reveal that the mAb treatment of infected mice preserves the functional activation of NK cells. Importantly, functional NK cells play an essential role in preventing immune dysfunction and inducing antiviral protective immunity upon mAb therapy. Thus, NK cell depletion in mAb-treated, viral-infected mice leads to the upregulation of molecules involved in immunosuppressive pathways (i.e., PD-1, PD-L1 and CD39) on dendritic cells and T cells. NK cell depletion also abrogates the vaccinal effects induced by mAb therapy. Our data also reveal a role for IFNγ-producing NK cells in the enhancement of the B-cell responses through the potentiation of the B-cell helper properties of neutrophils. These findings suggest that preserved NK cell functions and counts might be required for achieving mAb-induced protective immunity. They open new prospects for improving antiviral immunotherapies." @default.
- W3127966108 created "2021-02-15" @default.
- W3127966108 creator A5001630822 @default.
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- W3127966108 creator A5046875003 @default.
- W3127966108 creator A5048149676 @default.
- W3127966108 creator A5075600000 @default.
- W3127966108 date "2021-02-08" @default.
- W3127966108 modified "2023-09-24" @default.
- W3127966108 title "Immunomodulatory Role of NK Cells during Antiviral Antibody Therapy" @default.
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