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- W3127989055 abstract "In this issue of Blood, Kohlhaas et al report that constitutive activation of AKT is common in high-risk chronic lymphocytic lymphoma (CLL) and Richter transformation (RT), and demonstrate that genetic constitutive activation of AKT in B cells in the TCL1 mouse model of CLL drives transformation to an aggressive lymphoma. RT is the development of an aggressive lymphoma in the background of CLL, most typically diffuse large B-cell lymphoma, estimated to occur in 2% to 10% of patients. RT remains the greatest unmet need in CLL therapy in the era of targeted therapies, with poor response to treatment and very short overall survival, estimated at only 3.3 months in a recent multicenter retrospective study. Although some risk factors for developing RT are known, and include CLL with aberrant TP53, unmutated IGHV, NOTCH1 mutation, and stereotyped B-cell receptors, nonetheless most patients whose CLL has these features will not develop RT. Given the markedly worse outcome once RT develops, a major goal for the field must be to better predict which patients will develop this catastrophic event, and prevent it." @default.
- W3127989055 created "2021-02-15" @default.
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- W3127989055 date "2021-02-04" @default.
- W3127989055 modified "2023-10-14" @default.
- W3127989055 title "AKT: a key to RT?" @default.
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- W3127989055 doi "https://doi.org/10.1182/blood.2020008313" @default.
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