Matches in SemOpenAlex for { <https://semopenalex.org/work/W3127993378> ?p ?o ?g. }
- W3127993378 abstract "Altering the balance between energy intake and expenditure is a major strategy for treating obesity. Nonetheless, despite the progression in antiobesity drugs on appetite suppression, therapies aimed at increasing energy expenditure are limited. Here, knockout ofAKAP1, a signaling hub on outer mitochondrial membrane, renders mice resistant to diet-induced obesity.AKAP1 knockout significantly enhances energy expenditure and thermogenesis in brown adipose tissues (BATs) of obese mice. Restoring AKAP1 expression in BAT clearly reverses the beneficial antiobesity effect in AKAP1-/- mice. Mechanistically, AKAP1 remarkably decreases fatty acid β-oxidation (FAO) by phosphorylating ACSL1 to inhibit its activity in a protein-kinase-A-dependent manner and thus inhibits thermogenesis in brown adipocytes. Importantly, AKAP1 peptide inhibitor effectively alleviates diet-induced obesity and insulin resistance. Altogether, the findings demonstrate that AKAP1 functions as a brake of FAO to promote diet-induced obesity, which may be used as a potential therapeutic target for obesity." @default.
- W3127993378 created "2021-02-15" @default.
- W3127993378 creator A5005228021 @default.
- W3127993378 creator A5009138463 @default.
- W3127993378 creator A5010365898 @default.
- W3127993378 creator A5030921116 @default.
- W3127993378 creator A5037794174 @default.
- W3127993378 creator A5052628613 @default.
- W3127993378 creator A5062036444 @default.
- W3127993378 creator A5065124597 @default.
- W3127993378 creator A5065974789 @default.
- W3127993378 creator A5066602086 @default.
- W3127993378 creator A5075729175 @default.
- W3127993378 creator A5077859646 @default.
- W3127993378 creator A5083951615 @default.
- W3127993378 creator A5084688409 @default.
- W3127993378 creator A5091784014 @default.
- W3127993378 date "2021-02-01" @default.
- W3127993378 modified "2023-10-18" @default.
- W3127993378 title "<i>AKAP1</i> Deficiency Attenuates Diet‐Induced Obesity and Insulin Resistance by Promoting Fatty Acid Oxidation and Thermogenesis in Brown Adipocytes" @default.
- W3127993378 cites W1127264686 @default.
- W3127993378 cites W1706536722 @default.
- W3127993378 cites W1965079305 @default.
- W3127993378 cites W1983167131 @default.
- W3127993378 cites W1996234987 @default.
- W3127993378 cites W1997236468 @default.
- W3127993378 cites W2009773656 @default.
- W3127993378 cites W2019615270 @default.
- W3127993378 cites W2037918439 @default.
- W3127993378 cites W2039093059 @default.
- W3127993378 cites W2048416719 @default.
- W3127993378 cites W2051993213 @default.
- W3127993378 cites W2054248098 @default.
- W3127993378 cites W2060977160 @default.
- W3127993378 cites W2061505650 @default.
- W3127993378 cites W2079386976 @default.
- W3127993378 cites W2094025915 @default.
- W3127993378 cites W2102756292 @default.
- W3127993378 cites W2106970936 @default.
- W3127993378 cites W2111912667 @default.
- W3127993378 cites W2129326001 @default.
- W3127993378 cites W2134823147 @default.
- W3127993378 cites W2146625096 @default.
- W3127993378 cites W2150090192 @default.
- W3127993378 cites W2210368407 @default.
- W3127993378 cites W2235424783 @default.
- W3127993378 cites W2342575786 @default.
- W3127993378 cites W2345556940 @default.
- W3127993378 cites W2474050011 @default.
- W3127993378 cites W2588418869 @default.
- W3127993378 cites W2634393565 @default.
- W3127993378 cites W2674118028 @default.
- W3127993378 cites W270795111 @default.
- W3127993378 cites W2764142960 @default.
- W3127993378 cites W2767714100 @default.
- W3127993378 cites W2768393111 @default.
- W3127993378 cites W2770971791 @default.
- W3127993378 cites W2781978613 @default.
- W3127993378 cites W2783821934 @default.
- W3127993378 cites W2785534730 @default.
- W3127993378 cites W2797226667 @default.
- W3127993378 cites W2799469586 @default.
- W3127993378 cites W2887345219 @default.
- W3127993378 cites W2890532321 @default.
- W3127993378 cites W2891325408 @default.
- W3127993378 cites W2901643927 @default.
- W3127993378 cites W2902121131 @default.
- W3127993378 cites W2990096190 @default.
- W3127993378 cites W3002697594 @default.
- W3127993378 cites W3006847699 @default.
- W3127993378 cites W3028783478 @default.
- W3127993378 cites W4246830875 @default.
- W3127993378 doi "https://doi.org/10.1002/advs.202002794" @default.
- W3127993378 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7967052" @default.
- W3127993378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33747723" @default.
- W3127993378 hasPublicationYear "2021" @default.
- W3127993378 type Work @default.
- W3127993378 sameAs 3127993378 @default.
- W3127993378 citedByCount "13" @default.
- W3127993378 countsByYear W31279933782022 @default.
- W3127993378 countsByYear W31279933782023 @default.
- W3127993378 crossrefType "journal-article" @default.
- W3127993378 hasAuthorship W3127993378A5005228021 @default.
- W3127993378 hasAuthorship W3127993378A5009138463 @default.
- W3127993378 hasAuthorship W3127993378A5010365898 @default.
- W3127993378 hasAuthorship W3127993378A5030921116 @default.
- W3127993378 hasAuthorship W3127993378A5037794174 @default.
- W3127993378 hasAuthorship W3127993378A5052628613 @default.
- W3127993378 hasAuthorship W3127993378A5062036444 @default.
- W3127993378 hasAuthorship W3127993378A5065124597 @default.
- W3127993378 hasAuthorship W3127993378A5065974789 @default.
- W3127993378 hasAuthorship W3127993378A5066602086 @default.
- W3127993378 hasAuthorship W3127993378A5075729175 @default.
- W3127993378 hasAuthorship W3127993378A5077859646 @default.
- W3127993378 hasAuthorship W3127993378A5083951615 @default.
- W3127993378 hasAuthorship W3127993378A5084688409 @default.
- W3127993378 hasAuthorship W3127993378A5091784014 @default.
- W3127993378 hasBestOaLocation W31279933781 @default.
- W3127993378 hasConcept C126322002 @default.
- W3127993378 hasConcept C134018914 @default.