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- W3128002999 abstract "The synthetic antibacterial drug clofoctol (CFT) has long been used to treat respiratory tract infections in Europe. In recent years, the drug was found to target two biologically important proteins, the Cdc7/Dbf4 protein kinase complex and the mRNA-binding protein cold shock domain containing E1 (CSDE1), also known as upstream-of-N-Ras protein (UNR). These interactions are at the origin of the antitumor activity of CFT, recently evidenced in prostate cancer and neuroglioma. Drug–protein binding models provide a structural basis to guide the design of more potent anticancer compounds. A renewed interest in CFT can be anticipated for the treatment of cancers, and possibly Coronavirus 2019 (COVID-19)." @default.
- W3128002999 created "2021-02-15" @default.
- W3128002999 creator A5022442382 @default.
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- W3128002999 date "2021-05-01" @default.
- W3128002999 modified "2023-10-18" @default.
- W3128002999 title "A new horizon for the old antibacterial drug clofoctol" @default.
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- W3128002999 doi "https://doi.org/10.1016/j.drudis.2021.02.004" @default.
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