Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128010281> ?p ?o ?g. }
- W3128010281 abstract "Extracellular volume fraction (ECV) quantification with cardiovascular magnetic resonance (CMR) T1 mapping is a powerful tool for the characterization of focal or diffuse myocardial fibrosis. However, it is technically challenging to acquire high-quality T1 and ECV maps in small animals for preclinical research because of high heart rates and high respiration rates. In this work, we developed an electrocardiogram (ECG)-less, free-breathing ECV mapping method using motion-resolved CMR Multitasking on a 9.4 T small animal CMR system. The feasibility of characterizing diffuse myocardial fibrosis was tested in a rat heart failure model with preserved ejection fraction (HFpEF).High-salt fed rats diagnosed with HFpEF (n = 9) and control rats (n = 9) were imaged with the proposed ECV Multitasking technique. A 25-min exam, including two 4-min T1 Multitasking scans before and after gadolinium injection, were performed on each rat. It allows a cardiac temporal resolution of 20 ms for a heart rate of ~ 300 bpm. Myocardial ECV was calculated from the hematocrit (HCT) and fitted T1 values of the myocardium and the blood pool. Masson's trichrome stain was used to measure the extent of fibrosis. Welch's t-test was performed between control and HFpEF groups.ECV was significantly higher in the HFpEF group (22.4% ± 2.5% vs. 18.0% ± 2.1%, P = 0.0010). A moderate correlation between the ECV and the extent of fibrosis was found (R = 0.59, P = 0.0098).Motion-resolved ECV Multitasking CMR can quantify ECV in the rat myocardium at high heart rates without ECG triggering or respiratory gating. Elevated ECV found in the HFpEF group is consistent with previous human studies and well correlated with histological data. This technique has the potential to be a viable imaging tool for myocardial tissue characterization in small animal models." @default.
- W3128010281 created "2021-02-15" @default.
- W3128010281 creator A5004906371 @default.
- W3128010281 creator A5006408118 @default.
- W3128010281 creator A5046381230 @default.
- W3128010281 creator A5056243259 @default.
- W3128010281 creator A5065037360 @default.
- W3128010281 creator A5073931690 @default.
- W3128010281 creator A5076249210 @default.
- W3128010281 creator A5077747761 @default.
- W3128010281 date "2021-02-11" @default.
- W3128010281 modified "2023-10-16" @default.
- W3128010281 title "Electrocardiogram-less, free-breathing myocardial extracellular volume fraction mapping in small animals at high heart rates using motion-resolved cardiovascular magnetic resonance multitasking: a feasibility study in a heart failure with preserved ejection fraction rat model" @default.
- W3128010281 cites W1494833259 @default.
- W3128010281 cites W1972449305 @default.
- W3128010281 cites W1973189339 @default.
- W3128010281 cites W2013912476 @default.
- W3128010281 cites W2018385177 @default.
- W3128010281 cites W2024165284 @default.
- W3128010281 cites W2057054072 @default.
- W3128010281 cites W2072016638 @default.
- W3128010281 cites W2084593331 @default.
- W3128010281 cites W2101675075 @default.
- W3128010281 cites W2113577977 @default.
- W3128010281 cites W2117406892 @default.
- W3128010281 cites W2117892932 @default.
- W3128010281 cites W2136811556 @default.
- W3128010281 cites W2137784332 @default.
- W3128010281 cites W2143756095 @default.
- W3128010281 cites W2155150191 @default.
- W3128010281 cites W2155559652 @default.
- W3128010281 cites W2157265934 @default.
- W3128010281 cites W2159794025 @default.
- W3128010281 cites W2164111588 @default.
- W3128010281 cites W2171315526 @default.
- W3128010281 cites W2318892216 @default.
- W3128010281 cites W2329962224 @default.
- W3128010281 cites W2467085097 @default.
- W3128010281 cites W2552257291 @default.
- W3128010281 cites W2569397230 @default.
- W3128010281 cites W2746284654 @default.
- W3128010281 cites W2762062721 @default.
- W3128010281 cites W2769309750 @default.
- W3128010281 cites W2796032435 @default.
- W3128010281 cites W2797196654 @default.
- W3128010281 cites W2898298217 @default.
- W3128010281 cites W2901620844 @default.
- W3128010281 cites W3001242346 @default.
- W3128010281 doi "https://doi.org/10.1186/s12968-020-00699-9" @default.
- W3128010281 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7986488" @default.
- W3128010281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33752658" @default.
- W3128010281 hasPublicationYear "2021" @default.
- W3128010281 type Work @default.
- W3128010281 sameAs 3128010281 @default.
- W3128010281 citedByCount "4" @default.
- W3128010281 countsByYear W31280102812021 @default.
- W3128010281 countsByYear W31280102812022 @default.
- W3128010281 crossrefType "journal-article" @default.
- W3128010281 hasAuthorship W3128010281A5004906371 @default.
- W3128010281 hasAuthorship W3128010281A5006408118 @default.
- W3128010281 hasAuthorship W3128010281A5046381230 @default.
- W3128010281 hasAuthorship W3128010281A5056243259 @default.
- W3128010281 hasAuthorship W3128010281A5065037360 @default.
- W3128010281 hasAuthorship W3128010281A5073931690 @default.
- W3128010281 hasAuthorship W3128010281A5076249210 @default.
- W3128010281 hasAuthorship W3128010281A5077747761 @default.
- W3128010281 hasBestOaLocation W31280102811 @default.
- W3128010281 hasConcept C126322002 @default.
- W3128010281 hasConcept C126838900 @default.
- W3128010281 hasConcept C143409427 @default.
- W3128010281 hasConcept C164705383 @default.
- W3128010281 hasConcept C178853913 @default.
- W3128010281 hasConcept C185592680 @default.
- W3128010281 hasConcept C2113261 @default.
- W3128010281 hasConcept C2777099384 @default.
- W3128010281 hasConcept C2777953023 @default.
- W3128010281 hasConcept C2778198053 @default.
- W3128010281 hasConcept C2780559512 @default.
- W3128010281 hasConcept C28406088 @default.
- W3128010281 hasConcept C3018763269 @default.
- W3128010281 hasConcept C48277249 @default.
- W3128010281 hasConcept C55493867 @default.
- W3128010281 hasConcept C71924100 @default.
- W3128010281 hasConcept C78085059 @default.
- W3128010281 hasConcept C84393581 @default.
- W3128010281 hasConceptScore W3128010281C126322002 @default.
- W3128010281 hasConceptScore W3128010281C126838900 @default.
- W3128010281 hasConceptScore W3128010281C143409427 @default.
- W3128010281 hasConceptScore W3128010281C164705383 @default.
- W3128010281 hasConceptScore W3128010281C178853913 @default.
- W3128010281 hasConceptScore W3128010281C185592680 @default.
- W3128010281 hasConceptScore W3128010281C2113261 @default.
- W3128010281 hasConceptScore W3128010281C2777099384 @default.
- W3128010281 hasConceptScore W3128010281C2777953023 @default.
- W3128010281 hasConceptScore W3128010281C2778198053 @default.
- W3128010281 hasConceptScore W3128010281C2780559512 @default.
- W3128010281 hasConceptScore W3128010281C28406088 @default.
- W3128010281 hasConceptScore W3128010281C3018763269 @default.
- W3128010281 hasConceptScore W3128010281C48277249 @default.
- W3128010281 hasConceptScore W3128010281C55493867 @default.