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- W3128013065 abstract "The anti-CD20 antibody Rituximab to deplete CD20+ B cells is an effective treatment for rheumatoid arthritis and B cell malignancies, but is associated with an increased incidence of respiratory infections. Using mouse models we have investigated the consequences of B cell depletion on natural and acquired humoral immunity to Streptococcus pneumoniae . B cell depletion of naïve C57Bl/6 mice reduced natural IgM recognition of S. pneumoniae , but did not increase susceptibility to S. pneumoniae pneumonia. ELISA and flow cytometry assays demonstrated significantly reduced IgG and IgM recognition of S. pneumoniae in sera from mice treated with B cell depletion prior to S. pneumoniae nasopharyngeal colonization compared to untreated mice. Colonization induced antibody responses to protein rather than capsular antigen, and when measured using a protein array B cell depletion prior to colonization reduced serum levels of IgG to several protein antigens. However, B cell depleted S. pneumoniae colonized mice were still partially protected against both lung infection and septicemia when challenged with S. pneumoniae after reconstitution of their B cells. These data indicate that although B cell depletion markedly impairs antibody recognition of S. pneumoniae in colonized mice, some protective immunity is maintained, perhaps mediated by cellular immunity." @default.
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- W3128013065 date "2021-01-28" @default.
- W3128013065 modified "2023-09-25" @default.
- W3128013065 title "The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity to Streptococcus pneumoniae" @default.
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- W3128013065 doi "https://doi.org/10.3389/fimmu.2020.611661" @default.
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