FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128016934> ?p ?o ?g. }

• W3128016934 endingPage "135711" @default.
• W3128016934 startingPage "135711" @default.
• W3128016934 abstract "• Behavioural flexibility is mediated by orbitofrontal-hippocampal interaction. • NMDA-induced orbitofrontal-hippocampal lesions affect early phase reversal learning. • Learning deficits can not be reduced to motor deficits or anxiety-related behavior. Behavioural flexibility is a cognition-related function that enables subjects to adapt to a changing environment. Orbitofrontal cortex (OFC) and hippocampus (HC) have been involved in cognitive flexibility, but the interaction between these structures might be of particular functional significance. We applied a disconnection model in C57BL/6JRj mice to investigate the importance of OFC and ventral HC (vHC) interaction. Spatial acquisition and reversal performance in the Morris water maze (MWM) was compared between animals with small contralateral excitotoxic lesions to OFC and vHC, ipsilateral lesions (i.e., OFC-vHC lesions in the same hemisphere), as well as small bilateral OFC or vHC lesions. Spatial learning and memory performance was mostly unimpaired or only slightly impaired in our brain-lesioned animals compared to sham-lesioned control mice. However, contralaterally lesioned mice were significantly impaired during the early phase of reversal learning, whereas the other lesion groups performed similar to controls. These mice might also have experienced some difficulties using cognitively advanced search strategies. Additional non-mnemonic tests indicated that none of the defects could be reduced to motor, motivational or anxiety-related changes. Our findings support the particular role of PFC−HC interaction in advanced cognitive processes and flexibility." @default.
• W3128016934 created "2021-02-15" @default.
• W3128016934 creator A5036624743 @default.
• W3128016934 creator A5052605680 @default.
• W3128016934 creator A5073347333 @default.
• W3128016934 date "2021-04-01" @default.
• W3128016934 modified "2023-09-24" @default.
• W3128016934 title "Effects of orbitofrontal cortex and ventral hippocampus disconnection on spatial reversal learning" @default.
• W3128016934 cites W1604082481 @default.
• W3128016934 cites W1832907532 @default.
• W3128016934 cites W1969309428 @default.
• W3128016934 cites W1971078086 @default.
• W3128016934 cites W1984870586 @default.
• W3128016934 cites W1998585067 @default.
• W3128016934 cites W2000214310 @default.
• W3128016934 cites W2004136481 @default.
• W3128016934 cites W2009792683 @default.
• W3128016934 cites W2011835802 @default.
• W3128016934 cites W2015303467 @default.
• W3128016934 cites W2022561239 @default.
• W3128016934 cites W2023459882 @default.
• W3128016934 cites W2023595618 @default.
• W3128016934 cites W2024187681 @default.
• W3128016934 cites W2025940948 @default.
• W3128016934 cites W2027568409 @default.
• W3128016934 cites W2041613236 @default.
• W3128016934 cites W2045333348 @default.
• W3128016934 cites W2049115098 @default.
• W3128016934 cites W2050030726 @default.
• W3128016934 cites W2058094768 @default.
• W3128016934 cites W2063035524 @default.
• W3128016934 cites W2072060777 @default.
• W3128016934 cites W2086901501 @default.
• W3128016934 cites W2094260030 @default.
• W3128016934 cites W2098161132 @default.
• W3128016934 cites W2101353123 @default.
• W3128016934 cites W2102517209 @default.
• W3128016934 cites W2103740992 @default.
• W3128016934 cites W2114022439 @default.
• W3128016934 cites W2119259385 @default.
• W3128016934 cites W2130303756 @default.
• W3128016934 cites W2135755473 @default.
• W3128016934 cites W2138221880 @default.
• W3128016934 cites W2141041835 @default.
• W3128016934 cites W2142645762 @default.
• W3128016934 cites W2146215923 @default.
• W3128016934 cites W2158052449 @default.
• W3128016934 cites W2158147140 @default.
• W3128016934 cites W2159526067 @default.
• W3128016934 cites W2171802424 @default.
• W3128016934 cites W2294342312 @default.
• W3128016934 cites W2412783075 @default.
• W3128016934 cites W2487634804 @default.
• W3128016934 cites W2581553969 @default.
• W3128016934 cites W2621551027 @default.
• W3128016934 cites W2733572936 @default.
• W3128016934 cites W2748795632 @default.
• W3128016934 cites W2766519244 @default.
• W3128016934 cites W2778110282 @default.
• W3128016934 cites W2886908391 @default.
• W3128016934 cites W2896116243 @default.
• W3128016934 cites W2905265085 @default.
• W3128016934 cites W2906235672 @default.
• W3128016934 cites W4211081781 @default.
• W3128016934 cites W4248161408 @default.
• W3128016934 cites W644686294 @default.
• W3128016934 doi "https://doi.org/10.1016/j.neulet.2021.135711" @default.
• W3128016934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33571575" @default.
• W3128016934 hasPublicationYear "2021" @default.
• W3128016934 type Work @default.
• W3128016934 sameAs 3128016934 @default.
• W3128016934 citedByCount "4" @default.
• W3128016934 countsByYear W31280169342021 @default.
• W3128016934 countsByYear W31280169342022 @default.
• W3128016934 countsByYear W31280169342023 @default.
• W3128016934 crossrefType "journal-article" @default.
• W3128016934 hasAuthorship W3128016934A5036624743 @default.
• W3128016934 hasAuthorship W3128016934A5052605680 @default.
• W3128016934 hasAuthorship W3128016934A5073347333 @default.
• W3128016934 hasConcept C118552586 @default.
• W3128016934 hasConcept C148762608 @default.
• W3128016934 hasConcept C15744967 @default.
• W3128016934 hasConcept C169760540 @default.
• W3128016934 hasConcept C169900460 @default.
• W3128016934 hasConcept C17744445 @default.
• W3128016934 hasConcept C199539241 @default.
• W3128016934 hasConcept C2776559556 @default.
• W3128016934 hasConcept C2777681179 @default.
• W3128016934 hasConcept C2779085643 @default.
• W3128016934 hasConcept C2780371621 @default.
• W3128016934 hasConcept C2781156865 @default.
• W3128016934 hasConcept C2781161787 @default.
• W3128016934 hasConcept C2781195155 @default.
• W3128016934 hasConcept C2910500303 @default.
• W3128016934 hasConcept C44752575 @default.
• W3128016934 hasConcept C529278444 @default.
• W3128016934 hasConcept C66102695 @default.
• W3128016934 hasConceptScore W3128016934C118552586 @default.

• next