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- W3128020167 abstract "Immunotherapy guidelines state that significant cross-reactivity within and between Fagaceae and Betulaceae families enables the selection of one antigen to treat both families. We evaluated skin test reactivity to oak (Fagaceae) and alder (Betulaceae) pollens to optimize immunotherapy treatment in San Francisco (SF). A secondary goal was to analyze the utility of intradermal testing (IDT) for oak and alder. A total of 1577 patients were tested to oak mix RVW (red, Virginia live, white oak) and red alder pollen extracts (HollisterStier 1:20 w/v) from 1/1/2016 to 8/14/2020 at Kaiser Permanente SF. All patients underwent skin prick testing (SPT) and 75% of negative patients had IDT based on provider preference. Positive cut-off for SPT/IDT was wheal size ≥3 mm above negative control. Of those tested, 410 (26%) reacted to oak with 10 mm average SPT and 241 (15%) reacted to alder with 9.6 mm average. 211 reacted to both oak and alder encompassing 51% of oak-sensitized patients and 88% of alder-sensitized patients. Only 11/1842 intradermal tests (0.6%) showed reactivity and were excluded. This study shows a higher percentage of alder-sensitized patients are sensitized to oak (88%) than oak-sensitized patients to alder (51%). This is likely due to Aln g 1 homology to Que a 1 in the setting of higher oak prevalence in SF. We conclude that testing and treatment with oak will cover both Fagaceae and Betulaceae families in SF and potentially other oak-dominant regions. IDT yielded negligible reactivity and should not be routinely performed." @default.
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- W3128020167 date "2021-02-01" @default.
- W3128020167 modified "2023-09-27" @default.
- W3128020167 title "Comparative Incidence of Sensitivity to Oak and Alder in San Francisco" @default.
- W3128020167 doi "https://doi.org/10.1016/j.jaci.2020.12.318" @default.
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