FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128021254> ?p ?o ?g. }

• W3128021254 abstract "Abstract As they age, adult stem cells become more prone to functional decline, which is responsible for aging‐associated tissue degeneration and diseases. One goal of aging research is to identify drugs that can repair age‐associated tissue degeneration. Multiple organ development‐related signaling pathways have recently been demonstrated to have functions in tissue homeostasis and aging process. Therefore, in this study, we tested several chemicals that are essential for organ development to assess their ability to delay intestinal stem cell (ISC) aging and promote gut function in adult Drosophila . We found that taurine, a free amino acid that supports neurological development and tissue metabolism in humans, represses ISC hyperproliferation and restrains the intestinal functional decline seen in aged animals. We found that taurine represses age‐associated ISC hyperproliferation through a mechanism that eliminated endoplasmic reticulum (ER) stress by upregulation of the target genes of unfolded protein response in the ER (UPR ER ) and inhibiting the c‐Jun N‐terminal kinase (JNK) signaling. Our findings show that taurine plays a critical role in delaying the aging process in stem cells and suggest that it may be used as a natural compound for the treatment of age‐associated, or damage‐induced intestinal dysfunction in humans." @default.
• W3128021254 created "2021-02-15" @default.
• W3128021254 creator A5033183155 @default.
• W3128021254 creator A5034268473 @default.
• W3128021254 creator A5036203108 @default.
• W3128021254 creator A5038536791 @default.
• W3128021254 creator A5040045883 @default.
• W3128021254 creator A5047565130 @default.
• W3128021254 creator A5054484090 @default.
• W3128021254 creator A5065639795 @default.
• W3128021254 date "2021-02-09" @default.
• W3128021254 modified "2023-10-16" @default.
• W3128021254 title "Taurine represses age‐associated gut hyperplasia in <i>Drosophila</i> via counteracting endoplasmic reticulum stress" @default.
• W3128021254 cites W1486303545 @default.
• W3128021254 cites W1496487857 @default.
• W3128021254 cites W1835609627 @default.
• W3128021254 cites W1964956270 @default.
• W3128021254 cites W1986932941 @default.
• W3128021254 cites W2010583480 @default.
• W3128021254 cites W2012178564 @default.
• W3128021254 cites W2014676248 @default.
• W3128021254 cites W2028568142 @default.
• W3128021254 cites W2030791386 @default.
• W3128021254 cites W2031217639 @default.
• W3128021254 cites W2055646225 @default.
• W3128021254 cites W2068190453 @default.
• W3128021254 cites W2084810771 @default.
• W3128021254 cites W2103122175 @default.
• W3128021254 cites W2113431427 @default.
• W3128021254 cites W2119021294 @default.
• W3128021254 cites W2126525177 @default.
• W3128021254 cites W2144756395 @default.
• W3128021254 cites W2156762436 @default.
• W3128021254 cites W2162695817 @default.
• W3128021254 cites W2273290385 @default.
• W3128021254 cites W2577647246 @default.
• W3128021254 cites W2595342131 @default.
• W3128021254 cites W2735879215 @default.
• W3128021254 cites W2738794221 @default.
• W3128021254 cites W2767153955 @default.
• W3128021254 cites W2767362959 @default.
• W3128021254 cites W2775377849 @default.
• W3128021254 cites W2799874257 @default.
• W3128021254 cites W2802928954 @default.
• W3128021254 cites W2805831433 @default.
• W3128021254 cites W2884422234 @default.
• W3128021254 cites W2895124934 @default.
• W3128021254 cites W2917771007 @default.
• W3128021254 cites W2949628438 @default.
• W3128021254 cites W2959728234 @default.
• W3128021254 cites W2969505549 @default.
• W3128021254 cites W2970737070 @default.
• W3128021254 cites W2985538915 @default.
• W3128021254 cites W3008318402 @default.
• W3128021254 cites W301998504 @default.
• W3128021254 cites W3021982075 @default.
• W3128021254 cites W3041299558 @default.
• W3128021254 doi "https://doi.org/10.1111/acel.13319" @default.
• W3128021254 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7963329" @default.
• W3128021254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33559276" @default.
• W3128021254 hasPublicationYear "2021" @default.
• W3128021254 type Work @default.
• W3128021254 sameAs 3128021254 @default.
• W3128021254 citedByCount "10" @default.
• W3128021254 countsByYear W31280212542021 @default.
• W3128021254 countsByYear W31280212542022 @default.
• W3128021254 countsByYear W31280212542023 @default.
• W3128021254 crossrefType "journal-article" @default.
• W3128021254 hasAuthorship W3128021254A5033183155 @default.
• W3128021254 hasAuthorship W3128021254A5034268473 @default.
• W3128021254 hasAuthorship W3128021254A5036203108 @default.
• W3128021254 hasAuthorship W3128021254A5038536791 @default.
• W3128021254 hasAuthorship W3128021254A5040045883 @default.
• W3128021254 hasAuthorship W3128021254A5047565130 @default.
• W3128021254 hasAuthorship W3128021254A5054484090 @default.
• W3128021254 hasAuthorship W3128021254A5065639795 @default.
• W3128021254 hasBestOaLocation W31280212541 @default.
• W3128021254 hasConcept C104317684 @default.
• W3128021254 hasConcept C126322002 @default.
• W3128021254 hasConcept C127561419 @default.
• W3128021254 hasConcept C134018914 @default.
• W3128021254 hasConcept C139447449 @default.
• W3128021254 hasConcept C158617107 @default.
• W3128021254 hasConcept C2779701627 @default.
• W3128021254 hasConcept C28328180 @default.
• W3128021254 hasConcept C515207424 @default.
• W3128021254 hasConcept C55493867 @default.
• W3128021254 hasConcept C63645605 @default.
• W3128021254 hasConcept C71924100 @default.
• W3128021254 hasConcept C86803240 @default.
• W3128021254 hasConcept C95444343 @default.
• W3128021254 hasConceptScore W3128021254C104317684 @default.
• W3128021254 hasConceptScore W3128021254C126322002 @default.
• W3128021254 hasConceptScore W3128021254C127561419 @default.
• W3128021254 hasConceptScore W3128021254C134018914 @default.
• W3128021254 hasConceptScore W3128021254C139447449 @default.
• W3128021254 hasConceptScore W3128021254C158617107 @default.
• W3128021254 hasConceptScore W3128021254C2779701627 @default.
• W3128021254 hasConceptScore W3128021254C28328180 @default.
• W3128021254 hasConceptScore W3128021254C515207424 @default.

• next