FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128080147> ?p ?o ?g. }

• W3128080147 endingPage "147330" @default.
• W3128080147 startingPage "147330" @default.
• W3128080147 abstract "Autonomic neuropathy contributes to cardiovascular derangements induced by endotoxemia. In this communication, we tested the hypothesis that androgenic hormones improve arterial baroreflex dysfunction and predisposing neuroinflammatory response caused by endotoxemia in male rats. Baroreflex curves relating changes in heart rate to increases or decreases in blood pressure evoked by phenylephrine (PE) and sodium nitroprusside (SNP), respectively, were constructed in conscious sham-operated, castrated, and testosterone-replaced castrated rats treated with or without lipopolysaccharide (LPS, 10 mg/kg i.v.). Slopes of baroreflex curves were taken as measures of baroreflex sensitivity (BRS). In sham rats, LPS significantly reduced reflex bradycardia (BRSPE) and tachycardia (BRSSNP) and increased immunohistochemical expression of nuclear factor kappa B (NFκB) in heart and brainstem neurons of nucleus tractus solitarius (NTS) and rostral ventrolateral medulla (RVLM). The baroreflex depressant effect of LPS was maintained in castrated rats despite the remarkably attenuated inflammatory response. Testosterone replacement of castrated rats counteracted LPS-evoked BRSPE, but not BRSSNP, depression and increased cardiac, but not neuronal, NFκB expression. We also evaluated whether LPS responses could be affected following pharmacologic inhibition of androgenic biosynthetic pathways. Whereas none of LPS effects were altered in rats pretreated with formestane (aromatase inhibitor) or finasteride (5α-reductase inhibitor), the LPS-evoked BRSPE, but not BRSSNP, depression and cardiac and neuronal inflammation disappeared in rats pretreated with degarelix (gonadotropin-releasing hormone receptor blocker). Overall, despite the seemingly provocative role for the hypothalamic-pituitary-gonadal axis in the neuroinflammatory and baroreflex depressant effects of LPS, testosterone appears to distinctly modulate the two LPS effects." @default.
• W3128080147 created "2021-02-15" @default.
• W3128080147 creator A5030806129 @default.
• W3128080147 creator A5045120949 @default.
• W3128080147 creator A5054690152 @default.
• W3128080147 date "2021-04-01" @default.
• W3128080147 modified "2023-09-26" @default.
• W3128080147 title "Androgenic modulation of arterial baroreceptor dysfunction and neuroinflammation in endotoxic male rats" @default.
• W3128080147 cites W1508675418 @default.
• W3128080147 cites W1552829599 @default.
• W3128080147 cites W1571353934 @default.
• W3128080147 cites W1909363255 @default.
• W3128080147 cites W1967903515 @default.
• W3128080147 cites W1969164374 @default.
• W3128080147 cites W1980684007 @default.
• W3128080147 cites W1985408105 @default.
• W3128080147 cites W1989616443 @default.
• W3128080147 cites W1990047095 @default.
• W3128080147 cites W1993506310 @default.
• W3128080147 cites W1999187583 @default.
• W3128080147 cites W2000562431 @default.
• W3128080147 cites W2012561790 @default.
• W3128080147 cites W2013524245 @default.
• W3128080147 cites W2015548605 @default.
• W3128080147 cites W2018366225 @default.
• W3128080147 cites W2023908529 @default.
• W3128080147 cites W2024824028 @default.
• W3128080147 cites W2039608727 @default.
• W3128080147 cites W2050581082 @default.
• W3128080147 cites W2052953255 @default.
• W3128080147 cites W2055495965 @default.
• W3128080147 cites W2061840967 @default.
• W3128080147 cites W2067164831 @default.
• W3128080147 cites W2067268514 @default.
• W3128080147 cites W2069769057 @default.
• W3128080147 cites W2072296622 @default.
• W3128080147 cites W2072701076 @default.
• W3128080147 cites W2085435424 @default.
• W3128080147 cites W2086679559 @default.
• W3128080147 cites W2089283421 @default.
• W3128080147 cites W2091864125 @default.
• W3128080147 cites W2091897779 @default.
• W3128080147 cites W2091952300 @default.
• W3128080147 cites W2096822381 @default.
• W3128080147 cites W2097374381 @default.
• W3128080147 cites W2112583023 @default.
• W3128080147 cites W2113037196 @default.
• W3128080147 cites W2138851126 @default.
• W3128080147 cites W2142193433 @default.
• W3128080147 cites W2148256999 @default.
• W3128080147 cites W2164385322 @default.
• W3128080147 cites W2167994308 @default.
• W3128080147 cites W2322905272 @default.
• W3128080147 cites W2442851072 @default.
• W3128080147 cites W2508256791 @default.
• W3128080147 cites W2534747550 @default.
• W3128080147 cites W2605331481 @default.
• W3128080147 cites W2735527928 @default.
• W3128080147 cites W2783778185 @default.
• W3128080147 cites W2799653112 @default.
• W3128080147 cites W2897722618 @default.
• W3128080147 cites W2912362296 @default.
• W3128080147 cites W2940554674 @default.
• W3128080147 cites W2948773009 @default.
• W3128080147 cites W2950085450 @default.
• W3128080147 cites W2951937380 @default.
• W3128080147 cites W2964687162 @default.
• W3128080147 cites W3007633229 @default.
• W3128080147 doi "https://doi.org/10.1016/j.brainres.2021.147330" @default.
• W3128080147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33539800" @default.
• W3128080147 hasPublicationYear "2021" @default.
• W3128080147 type Work @default.
• W3128080147 sameAs 3128080147 @default.
• W3128080147 citedByCount "2" @default.
• W3128080147 countsByYear W31280801472021 @default.
• W3128080147 countsByYear W31280801472022 @default.
• W3128080147 crossrefType "journal-article" @default.
• W3128080147 hasAuthorship W3128080147A5030806129 @default.
• W3128080147 hasAuthorship W3128080147A5045120949 @default.
• W3128080147 hasAuthorship W3128080147A5054690152 @default.
• W3128080147 hasConcept C126322002 @default.
• W3128080147 hasConcept C134018914 @default.
• W3128080147 hasConcept C191237925 @default.
• W3128080147 hasConcept C2777952589 @default.
• W3128080147 hasConcept C2777953023 @default.
• W3128080147 hasConcept C33114225 @default.
• W3128080147 hasConcept C71924100 @default.
• W3128080147 hasConcept C79752029 @default.
• W3128080147 hasConcept C84393581 @default.
• W3128080147 hasConceptScore W3128080147C126322002 @default.
• W3128080147 hasConceptScore W3128080147C134018914 @default.
• W3128080147 hasConceptScore W3128080147C191237925 @default.
• W3128080147 hasConceptScore W3128080147C2777952589 @default.
• W3128080147 hasConceptScore W3128080147C2777953023 @default.
• W3128080147 hasConceptScore W3128080147C33114225 @default.
• W3128080147 hasConceptScore W3128080147C71924100 @default.
• W3128080147 hasConceptScore W3128080147C79752029 @default.
• W3128080147 hasConceptScore W3128080147C84393581 @default.

• next