Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128081107> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W3128081107 abstract "Glycolysis inhibition remains aspirational in cancer therapy. We recently described a promising phosphonate inhibitor of Enolase for cancers harboring deletions in ENO1. Here, we describe the application of nitroheterocycle pro-drugs capitalizing on tumor hypoxia. These bioreducible pro-drugs exhibit up to 14-fold greater potency under hypoxic conditions compared to normoxia and exhibit robust stability in biological fluids. Our work provides strong proof-of-concept for using bioreduction as a pro-drug delivery strategy in the context of Enolase inhibition." @default.
- W3128081107 created "2021-02-15" @default.
- W3128081107 creator A5013077867 @default.
- W3128081107 creator A5023947936 @default.
- W3128081107 creator A5024047574 @default.
- W3128081107 creator A5055700997 @default.
- W3128081107 creator A5087659696 @default.
- W3128081107 creator A5091138132 @default.
- W3128081107 date "2020-03-26" @default.
- W3128081107 modified "2023-09-25" @default.
- W3128081107 title "Bioreducible Pro-drug Inhibitors of Enolase" @default.
- W3128081107 doi "https://doi.org/10.26434/chemrxiv.12033303.v1" @default.
- W3128081107 hasPublicationYear "2020" @default.
- W3128081107 type Work @default.
- W3128081107 sameAs 3128081107 @default.
- W3128081107 citedByCount "2" @default.
- W3128081107 countsByYear W31280811072020 @default.
- W3128081107 countsByYear W31280811072022 @default.
- W3128081107 crossrefType "posted-content" @default.
- W3128081107 hasAuthorship W3128081107A5013077867 @default.
- W3128081107 hasAuthorship W3128081107A5023947936 @default.
- W3128081107 hasAuthorship W3128081107A5024047574 @default.
- W3128081107 hasAuthorship W3128081107A5055700997 @default.
- W3128081107 hasAuthorship W3128081107A5087659696 @default.
- W3128081107 hasAuthorship W3128081107A5091138132 @default.
- W3128081107 hasBestOaLocation W31280811071 @default.
- W3128081107 hasConcept C108215921 @default.
- W3128081107 hasConcept C151730666 @default.
- W3128081107 hasConcept C185592680 @default.
- W3128081107 hasConcept C188618488 @default.
- W3128081107 hasConcept C203014093 @default.
- W3128081107 hasConcept C204232928 @default.
- W3128081107 hasConcept C2777626080 @default.
- W3128081107 hasConcept C2779343474 @default.
- W3128081107 hasConcept C2780035454 @default.
- W3128081107 hasConcept C502942594 @default.
- W3128081107 hasConcept C55493867 @default.
- W3128081107 hasConcept C70721500 @default.
- W3128081107 hasConcept C86803240 @default.
- W3128081107 hasConcept C98274493 @default.
- W3128081107 hasConceptScore W3128081107C108215921 @default.
- W3128081107 hasConceptScore W3128081107C151730666 @default.
- W3128081107 hasConceptScore W3128081107C185592680 @default.
- W3128081107 hasConceptScore W3128081107C188618488 @default.
- W3128081107 hasConceptScore W3128081107C203014093 @default.
- W3128081107 hasConceptScore W3128081107C204232928 @default.
- W3128081107 hasConceptScore W3128081107C2777626080 @default.
- W3128081107 hasConceptScore W3128081107C2779343474 @default.
- W3128081107 hasConceptScore W3128081107C2780035454 @default.
- W3128081107 hasConceptScore W3128081107C502942594 @default.
- W3128081107 hasConceptScore W3128081107C55493867 @default.
- W3128081107 hasConceptScore W3128081107C70721500 @default.
- W3128081107 hasConceptScore W3128081107C86803240 @default.
- W3128081107 hasConceptScore W3128081107C98274493 @default.
- W3128081107 hasLocation W31280811071 @default.
- W3128081107 hasOpenAccess W3128081107 @default.
- W3128081107 hasPrimaryLocation W31280811071 @default.
- W3128081107 hasRelatedWork W142800689 @default.
- W3128081107 hasRelatedWork W1522159841 @default.
- W3128081107 hasRelatedWork W1995679978 @default.
- W3128081107 hasRelatedWork W2028582213 @default.
- W3128081107 hasRelatedWork W2037358675 @default.
- W3128081107 hasRelatedWork W2123424839 @default.
- W3128081107 hasRelatedWork W2553318679 @default.
- W3128081107 hasRelatedWork W2955528928 @default.
- W3128081107 hasRelatedWork W30436611 @default.
- W3128081107 hasRelatedWork W4306643349 @default.
- W3128081107 isParatext "false" @default.
- W3128081107 isRetracted "false" @default.
- W3128081107 magId "3128081107" @default.
- W3128081107 workType "article" @default.