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- W3128087256 abstract "This work investigates how docosahexaenoic acid (DHA) modifies the effect of Cholesterol (Chol) on the structural and dynamical properties of dipalmitoylphosphatidylcholine (DPPC) membrane. We employ low-cost and non-invasive methods: zeta potential (ZP), conductivity, density, and ultrasound velocity, complemented by molecular dynamics simulations. Our studies reveal that 30% of DHA added to the DPPC-Chol system tends to revert Chol action on a model lipid bilayer. Results obtained in this work shed light on the effect of polyunsaturated fatty acids - particularly DHA - on lipid membranes, with potential preventive applications in many diseases, e.g. neuronal as, Alzheimer's disease, and viral, as Covid-19." @default.
- W3128087256 created "2021-02-15" @default.
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- W3128087256 date "2021-06-01" @default.
- W3128087256 modified "2023-10-06" @default.
- W3128087256 title "A certain proportion of docosahexaenoic acid tends to revert structural and dynamical effects of cholesterol on lipid membranes" @default.
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- W3128087256 doi "https://doi.org/10.1016/j.bbamem.2021.183584" @default.
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