FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128105655> ?p ?o ?g. }

• W3128105655 endingPage "2002" @default.
• W3128105655 startingPage "1986" @default.
• W3128105655 abstract "Ligand-induced endocytosis of the immune receptor FLAGELLIN SENSING2 (FLS2) is critical for maintaining its proper abundance in the plasma membrane (PM) to initiate and subsequently down regulate cellular immune responses to bacterial flagellin or flg22-peptide. The molecular components governing PM abundance of FLS2, however, remain mostly unknown. Here, we identified Arabidopsis (Arabidopsis thaliana) DYNAMIN-RELATED PROTEIN1A (DRP1A), a member of a plant-specific family of large dynamin GTPases, as a critical contributor to ligand-induced endocytosis of FLS2 and its physiological roles in flg22-signaling and immunity against Pseudomonas syringae pv. tomato DC3000 bacteria in leaves. Notably, drp1a single mutants displayed similar flg22-defects as those previously reported for mutants in another dynamin-related protein, DRP2B, that was previously shown to colocalize with DRP1A. Our study also uncovered synergistic roles of DRP1A and DRP2B in plant growth and development as drp1a drp2b double mutants exhibited severely stunted roots and cotyledons, as well as defective cell shape, cytokinesis, and seedling lethality. Furthermore, drp1a drp2b double mutants hyperaccumulated FLS2 in the PM prior to flg22-treatment and exhibited a block in ligand-induced endocytosis of FLS2, indicating combinatorial roles for DRP1A and DRP1B in governing PM abundance of FLS2. However, the increased steady-state PM accumulation of FLS2 in drp1a drp2b double mutants did not result in increased flg22 responses. We propose that DRP1A and DRP2B are important for the regulation of PM-associated levels of FLS2 necessary to attain signaling competency to initiate distinct flg22 responses, potentially through modulating the lipid environment in defined PM domains." @default.
• W3128105655 created "2021-02-15" @default.
• W3128105655 creator A5012973740 @default.
• W3128105655 creator A5013895540 @default.
• W3128105655 creator A5017428056 @default.
• W3128105655 creator A5029588642 @default.
• W3128105655 creator A5033602096 @default.
• W3128105655 creator A5047684137 @default.
• W3128105655 creator A5077901314 @default.
• W3128105655 creator A5078636626 @default.
• W3128105655 creator A5087483621 @default.
• W3128105655 creator A5087666507 @default.
• W3128105655 date "2021-02-03" @default.
• W3128105655 modified "2023-10-14" @default.
• W3128105655 title "DYNAMIN-RELATED PROTEIN DRP1A functions with DRP2B in plant growth, flg22-immune responses, and endocytosis" @default.
• W3128105655 cites W1519305404 @default.
• W3128105655 cites W1562567267 @default.
• W3128105655 cites W1882584705 @default.
• W3128105655 cites W1898108646 @default.
• W3128105655 cites W1985068588 @default.
• W3128105655 cites W1990713505 @default.
• W3128105655 cites W2004435513 @default.
• W3128105655 cites W2004540275 @default.
• W3128105655 cites W2030359753 @default.
• W3128105655 cites W2033732626 @default.
• W3128105655 cites W2044032483 @default.
• W3128105655 cites W2058411072 @default.
• W3128105655 cites W2058637948 @default.
• W3128105655 cites W2070428731 @default.
• W3128105655 cites W2071717573 @default.
• W3128105655 cites W2076086772 @default.
• W3128105655 cites W2076324120 @default.
• W3128105655 cites W2079267430 @default.
• W3128105655 cites W2079540655 @default.
• W3128105655 cites W2092104784 @default.
• W3128105655 cites W2094485733 @default.
• W3128105655 cites W2104299767 @default.
• W3128105655 cites W2104664242 @default.
• W3128105655 cites W2122648379 @default.
• W3128105655 cites W2124505520 @default.
• W3128105655 cites W2126719623 @default.
• W3128105655 cites W2128967388 @default.
• W3128105655 cites W2141067927 @default.
• W3128105655 cites W2153151554 @default.
• W3128105655 cites W2153694091 @default.
• W3128105655 cites W2158557953 @default.
• W3128105655 cites W2158612914 @default.
• W3128105655 cites W2161053859 @default.
• W3128105655 cites W2161992890 @default.
• W3128105655 cites W22308802 @default.
• W3128105655 cites W2258081277 @default.
• W3128105655 cites W2407579356 @default.
• W3128105655 cites W2485069218 @default.
• W3128105655 cites W2521400209 @default.
• W3128105655 cites W2537248388 @default.
• W3128105655 cites W2582123300 @default.
• W3128105655 cites W2585406339 @default.
• W3128105655 cites W2588571662 @default.
• W3128105655 cites W2589303321 @default.
• W3128105655 cites W2593106793 @default.
• W3128105655 cites W2725106132 @default.
• W3128105655 cites W2767019886 @default.
• W3128105655 cites W2791857943 @default.
• W3128105655 cites W2800754584 @default.
• W3128105655 cites W2807502564 @default.
• W3128105655 cites W2890820189 @default.
• W3128105655 cites W2902212874 @default.
• W3128105655 cites W2903003989 @default.
• W3128105655 cites W2960653047 @default.
• W3128105655 cites W2965253958 @default.
• W3128105655 cites W2995292946 @default.
• W3128105655 cites W3006788103 @default.
• W3128105655 cites W3017359334 @default.
• W3128105655 cites W3019783516 @default.
• W3128105655 cites W3036972157 @default.
• W3128105655 doi "https://doi.org/10.1093/plphys/kiab024" @default.
• W3128105655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8133600" @default.
• W3128105655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33564884" @default.
• W3128105655 hasPublicationYear "2021" @default.
• W3128105655 type Work @default.
• W3128105655 sameAs 3128105655 @default.
• W3128105655 citedByCount "13" @default.
• W3128105655 countsByYear W31281056552021 @default.
• W3128105655 countsByYear W31281056552022 @default.
• W3128105655 countsByYear W31281056552023 @default.
• W3128105655 crossrefType "journal-article" @default.
• W3128105655 hasAuthorship W3128105655A5012973740 @default.
• W3128105655 hasAuthorship W3128105655A5013895540 @default.
• W3128105655 hasAuthorship W3128105655A5017428056 @default.
• W3128105655 hasAuthorship W3128105655A5029588642 @default.
• W3128105655 hasAuthorship W3128105655A5033602096 @default.
• W3128105655 hasAuthorship W3128105655A5047684137 @default.
• W3128105655 hasAuthorship W3128105655A5077901314 @default.
• W3128105655 hasAuthorship W3128105655A5078636626 @default.
• W3128105655 hasAuthorship W3128105655A5087483621 @default.
• W3128105655 hasAuthorship W3128105655A5087666507 @default.
• W3128105655 hasBestOaLocation W31281056551 @default.
• W3128105655 hasConcept C104317684 @default.

• next