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• W3128124802 abstract "Polycystic ovary syndrome (PCOS) is the most common endocrine diseases of fertile women and a major cause of infertility. The regulatory effects of DNA methylation on gene transcription and downstream lipid metabolism have not been explored in PCOS. In this study, MBD-seq and RNA-seq were performed on ovarian granulosa cells of PCOS patients and controls, and methylation specific PCR and quantitative polymerase chain reaction were used to validate the results. Then lipidomic profiling was conducted on serum of PCOS patients and controls using UPLC-MS. We identified 73 genes with differently methylated promoters and 830 differently expressed genes. The promoter regions of LPCAT1 and PCYT1A were hypermethylated, accompanied by downregulation of their messenger RNA expression, which may be involved in the regulation of PCOS through downstream glycerophospholipid metabolism and phosphatidylcholine synthesis. The lipid profiling results showed significant changes in 21 lipids, which demonstrated the disturbance in glycerophospholipid metabolism and glycerolipid metabolism pathways. Furthermore, the metabolites-genes interaction network was constructed to illustrate the association of aberrant methylome and transcriptome with lipidome alterations in glycerolipid and glycerophospholipid metabolism pathways. Our study suggested that the methylation silencing of LPCAT1 and PCYT1A may promote glycerophospholipids metabolism dysregulation, which provided a novel genetic and lipometabolic basis for the pathogenesis of PCOS." @default.
• W3128124802 created "2021-02-15" @default.
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• W3128124802 date "2021-01-31" @default.
• W3128124802 modified "2023-10-16" @default.
• W3128124802 title "Methylome and transcriptome profiling revealed epigenetic silencing of <i>LPCAT1</i> and <i>PCYT1A</i> associated with lipidome alterations in polycystic ovary syndrome" @default.
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• W3128124802 doi "https://doi.org/10.1002/jcp.30309" @default.
• W3128124802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33521992" @default.
• W3128124802 hasPublicationYear "2021" @default.
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