Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128133049> ?p ?o ?g. }
- W3128133049 abstract "Trypanosoma brucei, an important human parasite, has a flagellum that controls cell motility, morphogenesis, proliferation, and cell-cell communication. Inheritance of the newly assembled flagellum during the cell cycle requires the Polo-like kinase homolog TbPLK and the kinetoplastid-specific protein phosphatase KPP1, although whether TbPLK acts on KPP1 or vice versa has been unclear. Here, we showed that dephosphorylation of TbPLK on Thr125 by KPP1 maintained low TbPLK activity in the flagellum-associated hook complex structure, thereby ensuring proper flagellum positioning and attachment. This dephosphorylation event required the recognition of phosphorylated Thr198 in the activation loop of TbPLK by the N-terminal Plus3 domain of KPP1 and the dephosphorylation of phosphorylated Thr125 in TbPLK by the C-terminal catalytic domain of KPP1. Dephosphorylation of TbPLK by KPP1 prevented hyperphosphorylation of the hook complex protein TbCentrin2, thereby allowing timely dephosphorylation of phosphorylated TbCentrin2 for hook complex duplication and flagellum positioning and attachment. Thus, KPP1 attenuates TbPLK activity by dephosphorylating TbPLK to facilitate flagellum inheritance." @default.
- W3128133049 created "2021-02-15" @default.
- W3128133049 creator A5013109261 @default.
- W3128133049 creator A5029758151 @default.
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- W3128133049 date "2021-02-09" @default.
- W3128133049 modified "2023-09-25" @default.
- W3128133049 title "The kinetoplastid-specific phosphatase KPP1 attenuates PLK activity to facilitate flagellum inheritance in <i>Trypanosoma brucei</i>" @default.
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- W3128133049 doi "https://doi.org/10.1126/scisignal.abc6435" @default.
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