Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128135090> ?p ?o ?g. }
- W3128135090 endingPage "105932" @default.
- W3128135090 startingPage "105932" @default.
- W3128135090 abstract "Obesity is now a worldwide disease and is mainly attributable to increased body fat deposition. In a growing number of epidemiological studies, lutein has been revealed to have different degrees of anti-obesity properties, but the potential underlying mechanisms that have been reported are limited. Therefore, we aimed to clarify the protective effects of lutein against excessive lipid accumulation, and we explored the role of SIRT1 and SIRT1-mediated pathways both in abdominal adipose tissue and mature 3T3-L1 cells during lutein administration. In our design, male Sprague–Dawley rats were fed either control or high-fat diets with or without 25 mg/kg·bw/day lutein for 5 weeks. Additionally, differentiated 3T3-L1 cells were incubated with 40 μM lutein or 10 μM Ex527 for 24 h. Lutein supplementation decreased the body weight, abdominal fat index ratio, frequency and mean area of larger adipocytes in HE staining induced by the high-fat diet and then activated the expression of SIRT1 and thus upregulated FoxO1, ATGL, and HSL expression and downregulated SREBP-1, FAS, and ACC expression both in abdominal adipose tissue and differentiated 3T3-L1 cells. However, coincubation with Ex527 and lutein suppressed the activation of SIRT1 and reversed the expression of FoxO1, ATGL, HSL, SREBP-1, FAS, and ACC in comparison to those in the Lut group. Overall, we suggest that the effects of lutein on attenuating excessive lipid accumulation are dependent on the SIRT1-mediated pathway in vivo and in vitro, which indicates that lutein administration may be a potential strategy for preventing excessive lipid accumulation and obesity." @default.
- W3128135090 created "2021-02-15" @default.
- W3128135090 creator A5006788720 @default.
- W3128135090 creator A5007067761 @default.
- W3128135090 creator A5019167334 @default.
- W3128135090 creator A5020700917 @default.
- W3128135090 creator A5030011300 @default.
- W3128135090 creator A5033780771 @default.
- W3128135090 creator A5043839950 @default.
- W3128135090 creator A5080691790 @default.
- W3128135090 creator A5081087398 @default.
- W3128135090 creator A5086966849 @default.
- W3128135090 date "2021-04-01" @default.
- W3128135090 modified "2023-10-14" @default.
- W3128135090 title "Lutein attenuates excessive lipid accumulation in differentiated 3T3-L1 cells and abdominal adipose tissue of rats by the SIRT1-mediated pathway" @default.
- W3128135090 cites W1914965896 @default.
- W3128135090 cites W1915771847 @default.
- W3128135090 cites W1964801445 @default.
- W3128135090 cites W1966927487 @default.
- W3128135090 cites W1969408132 @default.
- W3128135090 cites W1973916444 @default.
- W3128135090 cites W1983050178 @default.
- W3128135090 cites W1988012917 @default.
- W3128135090 cites W1992047040 @default.
- W3128135090 cites W1996200651 @default.
- W3128135090 cites W1998136513 @default.
- W3128135090 cites W2006914860 @default.
- W3128135090 cites W2013651825 @default.
- W3128135090 cites W2040540364 @default.
- W3128135090 cites W2058381061 @default.
- W3128135090 cites W2064056874 @default.
- W3128135090 cites W2064866585 @default.
- W3128135090 cites W2065350215 @default.
- W3128135090 cites W2077834313 @default.
- W3128135090 cites W2077991483 @default.
- W3128135090 cites W2086169535 @default.
- W3128135090 cites W2086426509 @default.
- W3128135090 cites W2089352497 @default.
- W3128135090 cites W2090857330 @default.
- W3128135090 cites W2098789722 @default.
- W3128135090 cites W2109813770 @default.
- W3128135090 cites W2110271190 @default.
- W3128135090 cites W2121836743 @default.
- W3128135090 cites W2124898423 @default.
- W3128135090 cites W2127694087 @default.
- W3128135090 cites W2131256997 @default.
- W3128135090 cites W2140979952 @default.
- W3128135090 cites W2146842296 @default.
- W3128135090 cites W2147821881 @default.
- W3128135090 cites W2155844210 @default.
- W3128135090 cites W2159144087 @default.
- W3128135090 cites W2165226461 @default.
- W3128135090 cites W2169292626 @default.
- W3128135090 cites W2187962205 @default.
- W3128135090 cites W2190792874 @default.
- W3128135090 cites W2413456598 @default.
- W3128135090 cites W2472054870 @default.
- W3128135090 cites W2622115100 @default.
- W3128135090 cites W2755228276 @default.
- W3128135090 cites W2763071190 @default.
- W3128135090 cites W2771680905 @default.
- W3128135090 cites W2794613538 @default.
- W3128135090 cites W2969715092 @default.
- W3128135090 cites W4232976827 @default.
- W3128135090 doi "https://doi.org/10.1016/j.biocel.2021.105932" @default.
- W3128135090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33529717" @default.
- W3128135090 hasPublicationYear "2021" @default.
- W3128135090 type Work @default.
- W3128135090 sameAs 3128135090 @default.
- W3128135090 citedByCount "14" @default.
- W3128135090 countsByYear W31281350902022 @default.
- W3128135090 countsByYear W31281350902023 @default.
- W3128135090 crossrefType "journal-article" @default.
- W3128135090 hasAuthorship W3128135090A5006788720 @default.
- W3128135090 hasAuthorship W3128135090A5007067761 @default.
- W3128135090 hasAuthorship W3128135090A5019167334 @default.
- W3128135090 hasAuthorship W3128135090A5020700917 @default.
- W3128135090 hasAuthorship W3128135090A5030011300 @default.
- W3128135090 hasAuthorship W3128135090A5033780771 @default.
- W3128135090 hasAuthorship W3128135090A5043839950 @default.
- W3128135090 hasAuthorship W3128135090A5080691790 @default.
- W3128135090 hasAuthorship W3128135090A5081087398 @default.
- W3128135090 hasAuthorship W3128135090A5086966849 @default.
- W3128135090 hasConcept C126322002 @default.
- W3128135090 hasConcept C134018914 @default.
- W3128135090 hasConcept C171089720 @default.
- W3128135090 hasConcept C185592680 @default.
- W3128135090 hasConcept C194832188 @default.
- W3128135090 hasConcept C2778411929 @default.
- W3128135090 hasConcept C2780613262 @default.
- W3128135090 hasConcept C28781525 @default.
- W3128135090 hasConcept C511355011 @default.
- W3128135090 hasConcept C55493867 @default.
- W3128135090 hasConcept C71924100 @default.
- W3128135090 hasConceptScore W3128135090C126322002 @default.
- W3128135090 hasConceptScore W3128135090C134018914 @default.
- W3128135090 hasConceptScore W3128135090C171089720 @default.
- W3128135090 hasConceptScore W3128135090C185592680 @default.