FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128139904> ?p ?o ?g. }

• W3128139904 endingPage "62" @default.
• W3128139904 startingPage "55" @default.
• W3128139904 abstract "Rattlesnake's venom constitutes an important ecological trait that dynamically changes over time. Venoms of adult and juvenile rattleless rattlesnakes, Crotalus catalinensis , an endemic insular species from the Gulf of California, were compared by electrophoretic profile, fibrinogenolytic activity, and proteomic composition to assess ontogenetic variability. The SDS-PAGE profiles show important differences at 12, 22, and 45 kDa, which were prominent in adult samples and absent in juvenile samples, while bands around 20, 25, and 70 kDa are almost absent in adults. Both venoms hydrolyze Aa and Bb chains of fibrinogen generating different patterns of degradation products. This activity was partially inhibited by EDTA and PMSF and completely abolished only in the presence of both inhibitors. More than 260 proteins were identified and quantified in both venoms by proteomic analysis. Metalloproteinases (more than 60%), serine proteinases (14.5% in adult venom and 17.7% in juvenile venom), and C-type lectins (7.1 and 5.9%) represent the three most abundant toxin-related protein families. Bradykinin inhibitor peptides and L-amino acid oxidases were not detected in juvenile venom. A protein-specific comparison shows that adult and juvenile venom share about 30.5% of total toxin-related proteins, while 32% and 35% are exclusively present in adult and juvenile venoms, respectively. This work represents one of the first efforts to understand phenotypic diversity in the venom composition of insular rattlesnake species from Mexico. • First venomic analysis for a Crotalus microendemic population of one island ( Crotalus catalinensis ). • Venoms differ on its electrophoretic profile either in reduced and non-reduced conditions. • Both venoms hydrolyze alpha and beta chains of Fibrinogen generating different patterns of degradation products. • Metalloproteases, serine proteases and C-type Lectins are the three more abundant toxins in juvenile and adult samples. • More than 260 protein sequences were identified from which only 30% are shared by both venoms. The ontogenetic variation of the venom may explain efficiency in the capture of prey, especially in juveniles, which have a lower volume of venom than adults. The proteomic analysis of these venoms allows us to obtain a detailed catalog of the secreted toxins, which enables us to understand their biological effects better. The analysis of C. catalinensis venom showed ontogenetic variation in its composition, which could be explained by the difference in the diet of adults and juveniles." @default.
• W3128139904 created "2021-02-15" @default.
• W3128139904 creator A5000597179 @default.
• W3128139904 creator A5008724231 @default.
• W3128139904 creator A5018983900 @default.
• W3128139904 creator A5085546296 @default.
• W3128139904 date "2021-04-01" @default.
• W3128139904 modified "2023-10-01" @default.
• W3128139904 title "Proteomic comparison of adult and juvenile Santa Catalina rattlesnake (Crotalus catalinensis) venom" @default.
• W3128139904 cites W1984028033 @default.
• W3128139904 cites W1986887325 @default.
• W3128139904 cites W1990225332 @default.
• W3128139904 cites W1995526992 @default.
• W3128139904 cites W2003557975 @default.
• W3128139904 cites W2008964357 @default.
• W3128139904 cites W2029136951 @default.
• W3128139904 cites W2052731599 @default.
• W3128139904 cites W2053894359 @default.
• W3128139904 cites W2054716294 @default.
• W3128139904 cites W2059380727 @default.
• W3128139904 cites W2061198737 @default.
• W3128139904 cites W2071397228 @default.
• W3128139904 cites W2076707156 @default.
• W3128139904 cites W2089615360 @default.
• W3128139904 cites W2090117493 @default.
• W3128139904 cites W2100837269 @default.
• W3128139904 cites W2105498651 @default.
• W3128139904 cites W2111598908 @default.
• W3128139904 cites W2116582554 @default.
• W3128139904 cites W2143483161 @default.
• W3128139904 cites W2144076383 @default.
• W3128139904 cites W2150925001 @default.
• W3128139904 cites W2159377535 @default.
• W3128139904 cites W2173227271 @default.
• W3128139904 cites W2609099285 @default.
• W3128139904 cites W2737146600 @default.
• W3128139904 cites W2754620869 @default.
• W3128139904 cites W2801437936 @default.
• W3128139904 cites W2811255983 @default.
• W3128139904 cites W2902461242 @default.
• W3128139904 doi "https://doi.org/10.1016/j.toxicon.2021.01.014" @default.
• W3128139904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33545227" @default.
• W3128139904 hasPublicationYear "2021" @default.
• W3128139904 type Work @default.
• W3128139904 sameAs 3128139904 @default.
• W3128139904 citedByCount "2" @default.
• W3128139904 countsByYear W31281399042023 @default.
• W3128139904 crossrefType "journal-article" @default.
• W3128139904 hasAuthorship W3128139904A5000597179 @default.
• W3128139904 hasAuthorship W3128139904A5008724231 @default.
• W3128139904 hasAuthorship W3128139904A5018983900 @default.
• W3128139904 hasAuthorship W3128139904A5085546296 @default.
• W3128139904 hasConcept C115961737 @default.
• W3128139904 hasConcept C181199279 @default.
• W3128139904 hasConcept C18903297 @default.
• W3128139904 hasConcept C2777367657 @default.
• W3128139904 hasConcept C2779448229 @default.
• W3128139904 hasConcept C2780331750 @default.
• W3128139904 hasConcept C2780865716 @default.
• W3128139904 hasConcept C2908647359 @default.
• W3128139904 hasConcept C55493867 @default.
• W3128139904 hasConcept C71924100 @default.
• W3128139904 hasConcept C86803240 @default.
• W3128139904 hasConcept C90856448 @default.
• W3128139904 hasConcept C99454951 @default.
• W3128139904 hasConceptScore W3128139904C115961737 @default.
• W3128139904 hasConceptScore W3128139904C181199279 @default.
• W3128139904 hasConceptScore W3128139904C18903297 @default.
• W3128139904 hasConceptScore W3128139904C2777367657 @default.
• W3128139904 hasConceptScore W3128139904C2779448229 @default.
• W3128139904 hasConceptScore W3128139904C2780331750 @default.
• W3128139904 hasConceptScore W3128139904C2780865716 @default.
• W3128139904 hasConceptScore W3128139904C2908647359 @default.
• W3128139904 hasConceptScore W3128139904C55493867 @default.
• W3128139904 hasConceptScore W3128139904C71924100 @default.
• W3128139904 hasConceptScore W3128139904C86803240 @default.
• W3128139904 hasConceptScore W3128139904C90856448 @default.
• W3128139904 hasConceptScore W3128139904C99454951 @default.
• W3128139904 hasLocation W31281399041 @default.
• W3128139904 hasOpenAccess W3128139904 @default.
• W3128139904 hasPrimaryLocation W31281399041 @default.
• W3128139904 hasRelatedWork W1994884231 @default.
• W3128139904 hasRelatedWork W2050472316 @default.
• W3128139904 hasRelatedWork W2071397228 @default.
• W3128139904 hasRelatedWork W2100048451 @default.
• W3128139904 hasRelatedWork W2123638874 @default.
• W3128139904 hasRelatedWork W2172064109 @default.
• W3128139904 hasRelatedWork W3047721489 @default.
• W3128139904 hasRelatedWork W4249231449 @default.
• W3128139904 hasRelatedWork W4250006964 @default.
• W3128139904 hasRelatedWork W4251879418 @default.
• W3128139904 hasVolume "193" @default.
• W3128139904 isParatext "false" @default.
• W3128139904 isRetracted "false" @default.
• W3128139904 magId "3128139904" @default.
• W3128139904 workType "article" @default.