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- W3128142760 abstract "Abstract Alcohol use disorder (AUD) exacts a major personal, societal, and economic toll. Top-down control from the prefrontal cortex (PFC), a critical hub for decision making, executive, and other cognitive functions, is key for the regulation of alcohol consumption. Arousal exerts profound effects on cortical processing, allowing it to potentially modulate PFC functions relevant for alcohol consumption and AUD. Despite this, it is unclear whether and how arousal-mediated modulation of PFC circuits relates to voluntary alcohol drinking behaviors. Two-photon microscopy is ideally suited for dissecting the neural circuit mechanisms underlying the effect of alcohol on intact circuits in behaving animals. We addressed a major limitation of this technology by developing a novel behavioral paradigm for voluntary drinking in head-fixed mice. We recorded responses of layer 2/3 excitatory neurons in the anterior cingulate cortex (ACC) subdivision of the PFC as mice voluntarily consumed ethanol, along with video recording of the pupil to track momentary fluctuations in arousal. Ethanol consumption bidirectionally modified the activity of subsets of ACC neurons, both at slow (minutes) and fast (sub-second) time scales. Remarkably, we found that the coupling of arousal to ACC activity before drinking was associated with subsequent ethanol engagement behavior. In turn, ethanol consumption modulated neuronal-arousal coupling. Together, our results suggest neuronal-arousal coupling as a key biomarker for alcohol drinking and lays the groundwork for future studies to dissect the therapeutic potential of this process for AUD and other substance use disorders." @default.
- W3128142760 created "2021-02-15" @default.
- W3128142760 creator A5015708584 @default.
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- W3128142760 date "2021-02-02" @default.
- W3128142760 modified "2023-10-11" @default.
- W3128142760 title "Voluntary alcohol consumption disrupts coupling of prefrontal cortical activity to arousal" @default.
- W3128142760 cites W1501604912 @default.
- W3128142760 cites W1519578210 @default.
- W3128142760 cites W1562441344 @default.
- W3128142760 cites W1859582199 @default.
- W3128142760 cites W1905688313 @default.
- W3128142760 cites W1918713759 @default.
- W3128142760 cites W1964004976 @default.
- W3128142760 cites W1965232467 @default.
- W3128142760 cites W1975600479 @default.
- W3128142760 cites W1977137145 @default.
- W3128142760 cites W1977546136 @default.
- W3128142760 cites W1978125276 @default.
- W3128142760 cites W1980478962 @default.
- W3128142760 cites W1991882455 @default.
- W3128142760 cites W1992910467 @default.
- W3128142760 cites W1999088454 @default.
- W3128142760 cites W2006351341 @default.
- W3128142760 cites W2007270827 @default.
- W3128142760 cites W2011560929 @default.
- W3128142760 cites W2017119026 @default.
- W3128142760 cites W2017495352 @default.
- W3128142760 cites W2018303025 @default.
- W3128142760 cites W2022706198 @default.
- W3128142760 cites W2032340480 @default.
- W3128142760 cites W2034480183 @default.
- W3128142760 cites W2040728383 @default.
- W3128142760 cites W2042662796 @default.
- W3128142760 cites W2043311172 @default.
- W3128142760 cites W2056359334 @default.
- W3128142760 cites W2057104160 @default.
- W3128142760 cites W2060611129 @default.
- W3128142760 cites W2070851476 @default.
- W3128142760 cites W2071256705 @default.
- W3128142760 cites W2079960018 @default.
- W3128142760 cites W2080275784 @default.
- W3128142760 cites W2080894664 @default.
- W3128142760 cites W2086338669 @default.
- W3128142760 cites W2087809804 @default.
- W3128142760 cites W2089823661 @default.
- W3128142760 cites W2097237250 @default.
- W3128142760 cites W2105558714 @default.
- W3128142760 cites W2109461542 @default.
- W3128142760 cites W2111489584 @default.
- W3128142760 cites W2112038105 @default.
- W3128142760 cites W2123985235 @default.
- W3128142760 cites W2131864932 @default.
- W3128142760 cites W2148904500 @default.
- W3128142760 cites W2150305049 @default.
- W3128142760 cites W2151137320 @default.
- W3128142760 cites W2155717733 @default.
- W3128142760 cites W2159569422 @default.
- W3128142760 cites W2159646413 @default.
- W3128142760 cites W2171332611 @default.
- W3128142760 cites W2193980824 @default.
- W3128142760 cites W2210396547 @default.
- W3128142760 cites W2266381658 @default.
- W3128142760 cites W2386739164 @default.
- W3128142760 cites W2396428346 @default.
- W3128142760 cites W2397210210 @default.
- W3128142760 cites W2415438529 @default.
- W3128142760 cites W2469581795 @default.
- W3128142760 cites W2540493898 @default.
- W3128142760 cites W2547515170 @default.
- W3128142760 cites W2551360963 @default.
- W3128142760 cites W2553183677 @default.
- W3128142760 cites W2580178003 @default.
- W3128142760 cites W2594002025 @default.
- W3128142760 cites W2604729881 @default.
- W3128142760 cites W2610176726 @default.
- W3128142760 cites W2625897054 @default.
- W3128142760 cites W2741841195 @default.
- W3128142760 cites W2767077660 @default.
- W3128142760 cites W2767493192 @default.
- W3128142760 cites W2793050579 @default.
- W3128142760 cites W2802439163 @default.
- W3128142760 cites W2802499441 @default.
- W3128142760 cites W2803107452 @default.
- W3128142760 cites W2808738602 @default.
- W3128142760 cites W2883469761 @default.
- W3128142760 cites W2894521163 @default.
- W3128142760 cites W2903072834 @default.
- W3128142760 cites W2906911338 @default.
- W3128142760 cites W2910954796 @default.
- W3128142760 cites W2948555002 @default.
- W3128142760 cites W2952451491 @default.
- W3128142760 cites W2966139730 @default.
- W3128142760 cites W2971817407 @default.
- W3128142760 cites W2976024218 @default.
- W3128142760 cites W2980678765 @default.
- W3128142760 cites W2985092233 @default.