FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128156775> ?p ?o ?g. }

• W3128156775 endingPage "1439" @default.
• W3128156775 startingPage "1424" @default.
• W3128156775 abstract "Abstract Despite a remarkable increase in the genomic profiling of cancer, integration of genomic discoveries into clinical care has lagged behind. We report the feasibility of rapid identification of targetable mutations in 153 pediatric patients with relapsed/refractory or high-risk leukemias enrolled on a prospective clinical trial conducted by the LEAP Consortium. Eighteen percent of patients had a high confidence Tier 1 or 2 recommendation. We describe clinical responses in the 14% of patients with relapsed/refractory leukemia who received the matched targeted therapy. Further, in order to inform future targeted therapy for patients, we validated variants of uncertain significance, performed ex vivo drug-sensitivity testing in patient leukemia samples, and identified new combinations of targeted therapies in cell lines and patient-derived xenograft models. These data and our collaborative approach should inform the design of future precision medicine trials. Significance: Patients with relapsed/refractory leukemias face limited treatment options. Systematic integration of precision medicine efforts can inform therapy. We report the feasibility of identifying targetable mutations in children with leukemia and describe correlative biology studies validating therapeutic hypotheses and novel mutations. See related commentary by Bornhauser and Bourquin, p. 1322. This article is highlighted in the In This Issue feature, p. 1307" @default.
• W3128156775 created "2021-02-15" @default.
• W3128156775 creator A5001224002 @default.
• W3128156775 creator A5002930435 @default.
• W3128156775 creator A5003546101 @default.
• W3128156775 creator A5005966224 @default.
• W3128156775 creator A5007182073 @default.
• W3128156775 creator A5010840699 @default.
• W3128156775 creator A5011985711 @default.
• W3128156775 creator A5014227003 @default.
• W3128156775 creator A5014371302 @default.
• W3128156775 creator A5014545118 @default.
• W3128156775 creator A5018962418 @default.
• W3128156775 creator A5019172032 @default.
• W3128156775 creator A5019291158 @default.
• W3128156775 creator A5023214494 @default.
• W3128156775 creator A5024574848 @default.
• W3128156775 creator A5025319300 @default.
• W3128156775 creator A5026268460 @default.
• W3128156775 creator A5028407091 @default.
• W3128156775 creator A5033155482 @default.
• W3128156775 creator A5035004148 @default.
• W3128156775 creator A5036283202 @default.
• W3128156775 creator A5037169725 @default.
• W3128156775 creator A5037192036 @default.
• W3128156775 creator A5038829164 @default.
• W3128156775 creator A5038841996 @default.
• W3128156775 creator A5038903944 @default.
• W3128156775 creator A5040954385 @default.
• W3128156775 creator A5042483676 @default.
• W3128156775 creator A5048379858 @default.
• W3128156775 creator A5048549389 @default.
• W3128156775 creator A5048748466 @default.
• W3128156775 creator A5050851135 @default.
• W3128156775 creator A5053651370 @default.
• W3128156775 creator A5053710498 @default.
• W3128156775 creator A5056053037 @default.
• W3128156775 creator A5057602775 @default.
• W3128156775 creator A5058340446 @default.
• W3128156775 creator A5059056112 @default.
• W3128156775 creator A5063929028 @default.
• W3128156775 creator A5064010788 @default.
• W3128156775 creator A5066964026 @default.
• W3128156775 creator A5068523255 @default.
• W3128156775 creator A5071293141 @default.
• W3128156775 creator A5075519499 @default.
• W3128156775 creator A5076948857 @default.
• W3128156775 creator A5079420293 @default.
• W3128156775 creator A5081153366 @default.
• W3128156775 creator A5084637519 @default.
• W3128156775 creator A5087496453 @default.
• W3128156775 creator A5087508480 @default.
• W3128156775 creator A5087639347 @default.
• W3128156775 creator A5088572766 @default.
• W3128156775 creator A5091554825 @default.
• W3128156775 date "2021-02-09" @default.
• W3128156775 modified "2023-10-14" @default.
• W3128156775 title "Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium" @default.
• W3128156775 cites W1911918948 @default.
• W3128156775 cites W1970961996 @default.
• W3128156775 cites W1981709629 @default.
• W3128156775 cites W2004691500 @default.
• W3128156775 cites W2005909927 @default.
• W3128156775 cites W2009333774 @default.
• W3128156775 cites W2048002639 @default.
• W3128156775 cites W2049507332 @default.
• W3128156775 cites W2060605982 @default.
• W3128156775 cites W2067656626 @default.
• W3128156775 cites W2087784887 @default.
• W3128156775 cites W2109363337 @default.
• W3128156775 cites W2129702476 @default.
• W3128156775 cites W2134061682 @default.
• W3128156775 cites W2135675362 @default.
• W3128156775 cites W2148202982 @default.
• W3128156775 cites W2155046477 @default.
• W3128156775 cites W2158230102 @default.
• W3128156775 cites W2167334545 @default.
• W3128156775 cites W2215798291 @default.
• W3128156775 cites W2269136289 @default.
• W3128156775 cites W2272820807 @default.
• W3128156775 cites W2302493965 @default.
• W3128156775 cites W2414684615 @default.
• W3128156775 cites W2433919939 @default.
• W3128156775 cites W2439825102 @default.
• W3128156775 cites W2534055440 @default.
• W3128156775 cites W2564312835 @default.
• W3128156775 cites W2564365886 @default.
• W3128156775 cites W2566669267 @default.
• W3128156775 cites W2581891628 @default.
• W3128156775 cites W2596175104 @default.
• W3128156775 cites W2606654718 @default.
• W3128156775 cites W2654449699 @default.
• W3128156775 cites W2715749014 @default.
• W3128156775 cites W2733265822 @default.
• W3128156775 cites W2734356283 @default.
• W3128156775 cites W2742838159 @default.
• W3128156775 cites W2767347576 @default.
• W3128156775 cites W2770825793 @default.

• next