Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128163041> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W3128163041 abstract "Here, we apply chemical proteomics and untargeted lipidomics to assign a novel polyunsaturated fatty acid (PUFA)-specific triacylglycerol (TAG) lipase activity for diacylglycerol lipase-beta (DAGLβ) in macrophages. We demonstrate that DAGLβ but not DAGLα is expressed and active in bone marrow-derived macrophages (BMDMs) as determined by DAGL-directed activity-based protein profiling (ABPP). Genetic disruption of DAGLβ resulted in accumulation of cellular TAGs composed of PUFA but not saturated/low unsaturated FA counterparts, which is recapitulated in wild-type macrophages treated with a DAGLβ-selective inhibitor. Biochemical assays with synthetic substrates confirm PUFA-TAGs as authentic DAGLβ substrates. In summary, our findings identify DAGLβ as a PUFA-specific TAG lipase in primary macrophages." @default.
- W3128163041 created "2021-02-15" @default.
- W3128163041 creator A5000381341 @default.
- W3128163041 creator A5026232327 @default.
- W3128163041 creator A5042780334 @default.
- W3128163041 date "2019-01-01" @default.
- W3128163041 modified "2023-09-27" @default.
- W3128163041 title "DAGL-Beta Functions as a PUFA-Specific Triacylglycerol Lipase in Macrophages" @default.
- W3128163041 doi "https://doi.org/10.2139/ssrn.3464032" @default.
- W3128163041 hasPublicationYear "2019" @default.
- W3128163041 type Work @default.
- W3128163041 sameAs 3128163041 @default.
- W3128163041 citedByCount "0" @default.
- W3128163041 crossrefType "journal-article" @default.
- W3128163041 hasAuthorship W3128163041A5000381341 @default.
- W3128163041 hasAuthorship W3128163041A5026232327 @default.
- W3128163041 hasAuthorship W3128163041A5042780334 @default.
- W3128163041 hasConcept C181199279 @default.
- W3128163041 hasConcept C185592680 @default.
- W3128163041 hasConcept C19038510 @default.
- W3128163041 hasConcept C195794163 @default.
- W3128163041 hasConcept C2779697368 @default.
- W3128163041 hasConcept C2780902120 @default.
- W3128163041 hasConcept C2781227529 @default.
- W3128163041 hasConcept C36020004 @default.
- W3128163041 hasConcept C543025807 @default.
- W3128163041 hasConcept C55493867 @default.
- W3128163041 hasConcept C94879076 @default.
- W3128163041 hasConceptScore W3128163041C181199279 @default.
- W3128163041 hasConceptScore W3128163041C185592680 @default.
- W3128163041 hasConceptScore W3128163041C19038510 @default.
- W3128163041 hasConceptScore W3128163041C195794163 @default.
- W3128163041 hasConceptScore W3128163041C2779697368 @default.
- W3128163041 hasConceptScore W3128163041C2780902120 @default.
- W3128163041 hasConceptScore W3128163041C2781227529 @default.
- W3128163041 hasConceptScore W3128163041C36020004 @default.
- W3128163041 hasConceptScore W3128163041C543025807 @default.
- W3128163041 hasConceptScore W3128163041C55493867 @default.
- W3128163041 hasConceptScore W3128163041C94879076 @default.
- W3128163041 hasLocation W31281630411 @default.
- W3128163041 hasOpenAccess W3128163041 @default.
- W3128163041 hasPrimaryLocation W31281630411 @default.
- W3128163041 hasRelatedWork W1995176384 @default.
- W3128163041 hasRelatedWork W2001738533 @default.
- W3128163041 hasRelatedWork W2016779121 @default.
- W3128163041 hasRelatedWork W2036427101 @default.
- W3128163041 hasRelatedWork W2044116976 @default.
- W3128163041 hasRelatedWork W2066445744 @default.
- W3128163041 hasRelatedWork W2124374930 @default.
- W3128163041 hasRelatedWork W2344528832 @default.
- W3128163041 hasRelatedWork W2555278792 @default.
- W3128163041 hasRelatedWork W2733068425 @default.
- W3128163041 hasRelatedWork W2891914260 @default.
- W3128163041 hasRelatedWork W2912737431 @default.
- W3128163041 hasRelatedWork W2948914061 @default.
- W3128163041 hasRelatedWork W2964374428 @default.
- W3128163041 hasRelatedWork W2993739812 @default.
- W3128163041 hasRelatedWork W3001889433 @default.
- W3128163041 hasRelatedWork W3007424796 @default.
- W3128163041 hasRelatedWork W2571559608 @default.
- W3128163041 isParatext "false" @default.
- W3128163041 isRetracted "false" @default.
- W3128163041 magId "3128163041" @default.
- W3128163041 workType "article" @default.