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- W3128172011 abstract "Clinical trials have shown the efficacy of omalizumab in some forms of chronic inducible urticaria (CIndU), but real-life evidence is limited. Specifically, little is known about the long-term efficacy and safety of omalizumab in the treatment of patients with CIndU, and predictors of complete response and time to response remain unknown. This retrospective study included 36 CIndU patients (24 females) treated with omalizumab for six months. Efficacy and effects on QoL were assessed by use of the Urticaria Control Test (UCT) and the Dermatology Life Quality Index (DLQI), respectively, at baseline and each visit. Adverse events were documented. Omalizumab showed a significant continuous improvement in the scores of UCT and DLQI from baseline to each visit. A total of 77.8% of CIndU patients treated with omalizumab had well-controlled urticaria, and 61.1% of patients had no quality of life impairment. Higher baseline total serum is a possible biomarker predicting complete response in CIndU (121.0 vs. 42.9 kU/L, P=0.045). Slow complete responders who responded after 2 months are younger (33.3±4.5 vs. 28.0±6.8 years, P =0.034) and have lower baseline UCT scores (4.2 vs. 2.5, P =0.031). Five patients with complete control stopped their treatment and experienced a relapse after 3-14 weeks. They were successfully retreated with a complete response after the first administration. No treatment-related adverse events were recorded. Long-term treatment with omalizumab is effective and safe in patients with CIndU." @default.
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- W3128172011 date "2021-02-01" @default.
- W3128172011 modified "2023-10-12" @default.
- W3128172011 title "Omalizumab in Chronic Inducible Urticaria: a Real-Life Study of Efficacy, Safety, Predictors of Treatment Outcome, Time to Response and Relapse" @default.
- W3128172011 doi "https://doi.org/10.1016/j.jaci.2020.12.135" @default.
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